getGene.RdRetrieve a specific gene from the CIViC DB
getGene(id, identifier_type = "civic_id")
| id | ID of the gene of interest |
|---|---|
| identifier_type | Type of gene identifier (entrez_id, entrez_symbol, civic_id) |
An S3 Object of type civic_api containing the content, url, and response
getGene(id = 1)#> $content #> $content$id #> [1] 1 #> #> $content$name #> [1] "ALK" #> #> $content$entrez_id #> [1] 238 #> #> $content$description #> [1] "ALK amplifications, fusions and mutations have been shown to be driving events in non-small cell lung cancer. While crizontinib has demonstrated efficacy in treating the amplification, mutations in ALK have been shown to confer resistance to current tyrosine kinase inhibitors. Second-generation TKI's have seen varied success in treating these resistant cases, and the HSP90 inhibitor 17-AAG has been shown to be cytostatic in ALK-altered cell lines." #> #> $content$variants #> $content$variants[[1]] #> $content$variants[[1]]$name #> [1] "CAD-ALK" #> #> $content$variants[[1]]$id #> [1] 2769 #> #> $content$variants[[1]]$evidence_items #> $content$variants[[1]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[1]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[2]] #> $content$variants[[2]]$name #> [1] "EML4-ALK L1152R" #> #> $content$variants[[2]]$id #> [1] 307 #> #> $content$variants[[2]]$evidence_items #> $content$variants[[2]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[3]] #> $content$variants[[3]]$name #> [1] "L1198F" #> #> $content$variants[[3]]$id #> [1] 1275 #> #> $content$variants[[3]]$evidence_items #> $content$variants[[3]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[3]]$evidence_items$rejected_count #> [1] 1 #> #> $content$variants[[3]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[4]] #> $content$variants[[4]]$name #> [1] "HIP1-ALK I1171N" #> #> $content$variants[[4]]$id #> [1] 588 #> #> $content$variants[[4]]$evidence_items #> $content$variants[[4]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[4]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$variants[[5]] #> $content$variants[[5]]$name #> [1] "L1196Q" #> #> $content$variants[[5]]$id #> [1] 1553 #> #> $content$variants[[5]]$evidence_items #> $content$variants[[5]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[5]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[6]] #> $content$variants[[6]]$name #> [1] "RANBP2-ALK" #> #> $content$variants[[6]]$id #> [1] 514 #> #> $content$variants[[6]]$evidence_items #> $content$variants[[6]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[6]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[7]] #> $content$variants[[7]]$name #> [1] "F1174C" #> #> $content$variants[[7]]$id #> [1] 1492 #> #> $content$variants[[7]]$evidence_items #> $content$variants[[7]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[7]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[8]] #> $content$variants[[8]]$name #> [1] "R214H" #> #> $content$variants[[8]]$id #> [1] 1683 #> #> $content$variants[[8]]$evidence_items #> $content$variants[[8]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[8]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[8]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[9]] #> $content$variants[[9]]$name #> [1] "EML4-ALK C1156Y" #> #> $content$variants[[9]]$id #> [1] 6 #> #> $content$variants[[9]]$evidence_items #> $content$variants[[9]]$evidence_items$accepted_count #> [1] 3 #> #> $content$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[9]]$evidence_items$submitted_count #> [1] 5 #> #> #> #> $content$variants[[10]] #> $content$variants[[10]]$name #> [1] "T1151M" #> #> $content$variants[[10]]$id #> [1] 1493 #> #> $content$variants[[10]]$evidence_items #> $content$variants[[10]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[10]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[11]] #> $content$variants[[11]]$name #> [1] "EML4-ALK V1180L" #> #> $content$variants[[11]]$id #> [1] 528 #> #> $content$variants[[11]]$evidence_items #> $content$variants[[11]]$evidence_items$accepted_count #> [1] 5 #> #> $content$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[11]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[12]] #> $content$variants[[12]]$name #> [1] "R1192P" #> #> $content$variants[[12]]$id #> [1] 1661 #> #> $content$variants[[12]]$evidence_items #> $content$variants[[12]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[12]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[12]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[13]] #> $content$variants[[13]]$name #> [1] "DEL4-11" #> #> $content$variants[[13]]$id #> [1] 550 #> #> $content$variants[[13]]$evidence_items #> $content$variants[[13]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[13]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[14]] #> $content$variants[[14]]$name #> [1] "EML6-ALK E1;A20 and FBXO11-ALK E1;A20" #> #> $content$variants[[14]]$id #> [1] 2750 #> #> $content$variants[[14]]$evidence_items #> $content$variants[[14]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[14]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[15]] #> $content$variants[[15]]$name #> [1] "MUTATION" #> #> $content$variants[[15]]$id #> [1] 512 #> #> $content$variants[[15]]$evidence_items #> $content$variants[[15]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[15]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[16]] #> $content$variants[[16]]$name #> [1] "EML4-ALK" #> #> $content$variants[[16]]$id #> [1] 5 #> #> $content$variants[[16]]$evidence_items #> $content$variants[[16]]$evidence_items$accepted_count #> [1] 7 #> #> $content$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[16]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[17]] #> $content$variants[[17]]$name #> [1] "EML4-ALK S1206Y" #> #> $content$variants[[17]]$id #> [1] 172 #> #> $content$variants[[17]]$evidence_items #> $content$variants[[17]]$evidence_items$accepted_count #> [1] 2 #> #> $content$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[17]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$variants[[18]] #> $content$variants[[18]]$name #> [1] "EML4-ALK AMPLIFICATION" #> #> $content$variants[[18]]$id #> [1] 170 #> #> $content$variants[[18]]$evidence_items #> $content$variants[[18]]$evidence_items$accepted_count #> [1] 3 #> #> $content$variants[[18]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[19]] #> $content$variants[[19]]$name #> [1] "CLTC-ALK" #> #> $content$variants[[19]]$id #> [1] 520 #> #> $content$variants[[19]]$evidence_items #> $content$variants[[19]]$evidence_items$accepted_count #> [1] 3 #> #> $content$variants[[19]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[19]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[20]] #> $content$variants[[20]]$name #> [1] "EML4-ALK E2;A20" #> #> $content$variants[[20]]$id #> [1] 501 #> #> $content$variants[[20]]$evidence_items #> $content$variants[[20]]$evidence_items$accepted_count #> [1] 2 #> #> $content$variants[[20]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[20]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[21]] #> $content$variants[[21]]$name #> [1] "EML4-ALK E6;A20" #> #> $content$variants[[21]]$id #> [1] 503 #> #> $content$variants[[21]]$evidence_items #> $content$variants[[21]]$evidence_items$accepted_count #> [1] 7 #> #> $content$variants[[21]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[21]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[22]] #> $content$variants[[22]]$name #> [1] "R1275Q" #> #> $content$variants[[22]]$id #> [1] 9 #> #> $content$variants[[22]]$evidence_items #> $content$variants[[22]]$evidence_items$accepted_count #> [1] 6 #> #> $content$variants[[22]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[22]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$variants[[23]] #> $content$variants[[23]]$name #> [1] "F1245V" #> #> $content$variants[[23]]$id #> [1] 1295 #> #> $content$variants[[23]]$evidence_items #> $content$variants[[23]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[23]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[23]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$variants[[24]] #> $content$variants[[24]]$name #> [1] "ALTERNATIVE TRANSCRIPT (ATI)" #> #> $content$variants[[24]]$id #> [1] 839 #> #> $content$variants[[24]]$evidence_items #> $content$variants[[24]]$evidence_items$accepted_count #> [1] 2 #> #> $content$variants[[24]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[24]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[25]] #> $content$variants[[25]]$name #> [1] "EML4-ALK I1171S" #> #> $content$variants[[25]]$id #> [1] 589 #> #> $content$variants[[25]]$evidence_items #> $content$variants[[25]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[25]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[25]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[26]] #> $content$variants[[26]]$name #> [1] "F1174V" #> #> $content$variants[[26]]$id #> [1] 1505 #> #> $content$variants[[26]]$evidence_items #> $content$variants[[26]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[26]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[26]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[27]] #> $content$variants[[27]]$name #> [1] "F1174L" #> #> $content$variants[[27]]$id #> [1] 8 #> #> $content$variants[[27]]$evidence_items #> $content$variants[[27]]$evidence_items$accepted_count #> [1] 9 #> #> $content$variants[[27]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[27]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$variants[[28]] #> $content$variants[[28]]$name #> [1] "STRN-ALK" #> #> $content$variants[[28]]$id #> [1] 2218 #> #> $content$variants[[28]]$evidence_items #> $content$variants[[28]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[28]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[28]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[29]] #> $content$variants[[29]]$name #> [1] "ALK FUSION G1269A" #> #> $content$variants[[29]]$id #> [1] 552 #> #> $content$variants[[29]]$evidence_items #> $content$variants[[29]]$evidence_items$accepted_count #> [1] 4 #> #> $content$variants[[29]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[29]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[30]] #> $content$variants[[30]]$name #> [1] "ALK FUSION G1202R" #> #> $content$variants[[30]]$id #> [1] 171 #> #> $content$variants[[30]]$evidence_items #> $content$variants[[30]]$evidence_items$accepted_count #> [1] 6 #> #> $content$variants[[30]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[30]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$variants[[31]] #> $content$variants[[31]]$name #> [1] "ALK FUSION I1171" #> #> $content$variants[[31]]$id #> [1] 527 #> #> $content$variants[[31]]$evidence_items #> $content$variants[[31]]$evidence_items$accepted_count #> [1] 7 #> #> $content$variants[[31]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[31]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$variants[[32]] #> $content$variants[[32]]$name #> [1] "EML4-ALK G1269A" #> #> $content$variants[[32]]$id #> [1] 308 #> #> $content$variants[[32]]$evidence_items #> $content$variants[[32]]$evidence_items$accepted_count #> [1] 2 #> #> $content$variants[[32]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[32]]$evidence_items$submitted_count #> [1] 5 #> #> #> #> $content$variants[[33]] #> $content$variants[[33]]$name #> [1] "EML4-ALK L1196M" #> #> $content$variants[[33]]$id #> [1] 7 #> #> $content$variants[[33]]$evidence_items #> $content$variants[[33]]$evidence_items$accepted_count #> [1] 4 #> #> $content$variants[[33]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[33]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$variants[[34]] #> $content$variants[[34]]$name #> [1] "F1245C" #> #> $content$variants[[34]]$id #> [1] 549 #> #> $content$variants[[34]]$evidence_items #> $content$variants[[34]]$evidence_items$accepted_count #> [1] 2 #> #> $content$variants[[34]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[34]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[35]] #> $content$variants[[35]]$name #> [1] "FUSION" #> #> $content$variants[[35]]$id #> [1] 2694 #> #> $content$variants[[35]]$evidence_items #> $content$variants[[35]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[35]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[35]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$variants[[36]] #> $content$variants[[36]]$name #> [1] "ALK FUSION" #> #> $content$variants[[36]]$id #> [1] 2220 #> #> $content$variants[[36]]$evidence_items #> $content$variants[[36]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[36]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[36]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[37]] #> $content$variants[[37]]$name #> [1] "L1198P" #> #> $content$variants[[37]]$id #> [1] 1556 #> #> $content$variants[[37]]$evidence_items #> $content$variants[[37]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[37]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[37]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[38]] #> $content$variants[[38]]$name #> [1] "L1152P" #> #> $content$variants[[38]]$id #> [1] 1554 #> #> $content$variants[[38]]$evidence_items #> $content$variants[[38]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[38]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[38]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[39]] #> $content$variants[[39]]$name #> [1] "EML4-ALK E20;A20" #> #> $content$variants[[39]]$id #> [1] 500 #> #> $content$variants[[39]]$evidence_items #> $content$variants[[39]]$evidence_items$accepted_count #> [1] 4 #> #> $content$variants[[39]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[39]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[40]] #> $content$variants[[40]]$name #> [1] "ALK FUSIONS" #> #> $content$variants[[40]]$id #> [1] 499 #> #> $content$variants[[40]]$evidence_items #> $content$variants[[40]]$evidence_items$accepted_count #> [1] 26 #> #> $content$variants[[40]]$evidence_items$rejected_count #> [1] 2 #> #> $content$variants[[40]]$evidence_items$submitted_count #> [1] 6 #> #> #> #> $content$variants[[41]] #> $content$variants[[41]]$name #> [1] "ALK FUSION F1245C" #> #> $content$variants[[41]]$id #> [1] 551 #> #> $content$variants[[41]]$evidence_items #> $content$variants[[41]]$evidence_items$accepted_count #> [1] 3 #> #> $content$variants[[41]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[41]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[42]] #> $content$variants[[42]]$name #> [1] "EML4-ALK C1156Y–L1198F" #> #> $content$variants[[42]]$id #> [1] 352 #> #> $content$variants[[42]]$evidence_items #> $content$variants[[42]]$evidence_items$accepted_count #> [1] 2 #> #> $content$variants[[42]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[42]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[43]] #> $content$variants[[43]]$name #> [1] "NPM-ALK" #> #> $content$variants[[43]]$id #> [1] 513 #> #> $content$variants[[43]]$evidence_items #> $content$variants[[43]]$evidence_items$accepted_count #> [1] 3 #> #> $content$variants[[43]]$evidence_items$rejected_count #> [1] 1 #> #> $content$variants[[43]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[44]] #> $content$variants[[44]]$name #> [1] "OVEREXPRESSION" #> #> $content$variants[[44]]$id #> [1] 2635 #> #> $content$variants[[44]]$evidence_items #> $content$variants[[44]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[44]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[44]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[45]] #> $content$variants[[45]]$name #> [1] "EML4-ALK C1156Y–L1196M" #> #> $content$variants[[45]]$id #> [1] 608 #> #> $content$variants[[45]]$evidence_items #> $content$variants[[45]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[45]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[45]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[46]] #> $content$variants[[46]]$name #> [1] "EML4-ALK T1151INST" #> #> $content$variants[[46]]$id #> [1] 173 #> #> $content$variants[[46]]$evidence_items #> $content$variants[[46]]$evidence_items$accepted_count #> [1] 4 #> #> $content$variants[[46]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[46]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> #> $content$aliases #> $content$aliases[[1]] #> [1] "ALK" #> #> $content$aliases[[2]] #> [1] "NBLST3" #> #> $content$aliases[[3]] #> [1] "CD246" #> #> #> $content$type #> [1] "gene" #> #> $content$lifecycle_actions #> named list() #> #> $content$sources #> $content$sources[[1]] #> $content$sources[[1]]$id #> [1] 1 #> #> $content$sources[[1]]$name #> [1] "ALK inhibitors and advanced non-small cell lung cancer (review)." #> #> $content$sources[[1]]$citation #> [1] "Rossi et al., 2014, Int. J. Oncol." #> #> $content$sources[[1]]$citation_id #> [1] "24889366" #> #> $content$sources[[1]]$source_type #> [1] "PubMed" #> #> $content$sources[[1]]$asco_abstract_id #> NULL #> #> $content$sources[[1]]$source_url #> [1] "http://www.ncbi.nlm.nih.gov/pubmed/24889366" #> #> $content$sources[[1]]$open_access #> NULL #> #> $content$sources[[1]]$pmc_id #> NULL #> #> $content$sources[[1]]$publication_date #> $content$sources[[1]]$publication_date$year #> [1] 2014 #> #> $content$sources[[1]]$publication_date$month #> [1] 8 #> #> #> $content$sources[[1]]$journal #> [1] "Int. J. Oncol." #> #> $content$sources[[1]]$full_journal_title #> [1] "International journal of oncology" #> #> $content$sources[[1]]$status #> [1] "fully curated" #> #> $content$sources[[1]]$is_review #> [1] FALSE #> #> $content$sources[[1]]$clinical_trials #> list() #> #> #> $content$sources[[2]] #> $content$sources[[2]]$id #> [1] 2 #> #> $content$sources[[2]]$name #> [1] "ALK in lung cancer: past, present, and future." #> #> $content$sources[[2]]$citation #> [1] "Shaw et al., 2013, J. Clin. Oncol." #> #> $content$sources[[2]]$citation_id #> [1] "23401436" #> #> $content$sources[[2]]$source_type #> [1] "PubMed" #> #> $content$sources[[2]]$asco_abstract_id #> NULL #> #> $content$sources[[2]]$source_url #> [1] "http://www.ncbi.nlm.nih.gov/pubmed/23401436" #> #> $content$sources[[2]]$open_access #> [1] TRUE #> #> $content$sources[[2]]$pmc_id #> [1] "PMC4209068" #> #> $content$sources[[2]]$publication_date #> $content$sources[[2]]$publication_date$year #> [1] 2013 #> #> $content$sources[[2]]$publication_date$month #> [1] 3 #> #> $content$sources[[2]]$publication_date$day #> [1] 10 #> #> #> $content$sources[[2]]$journal #> [1] "J. Clin. Oncol." #> #> $content$sources[[2]]$full_journal_title #> [1] "Journal of clinical oncology : official journal of the American Society of Clinical Oncology" #> #> $content$sources[[2]]$status #> [1] "fully curated" #> #> $content$sources[[2]]$is_review #> [1] FALSE #> #> $content$sources[[2]]$clinical_trials #> list() #> #> #> #> $content$provisional_values #> named list() #> #> $content$errors #> named list() #> #> #> $url #> [1] "https://civicdb.org/api/genes/1" #> #> $response #> Response [https://civicdb.org/api/genes/1?identifier_type=civic_id] #> Date: 2019-09-03 16:44 #> Status: 200 #> Content-Type: application/json; charset=utf-8 #> Size: 6.75 kB #> #> #> attr(,"class") #> [1] "civic_api"getGene(id = "ALK", identifier_type = "entrez_symbol")#> $content #> $content$id #> [1] 1 #> #> $content$name #> [1] "ALK" #> #> $content$entrez_id #> [1] 238 #> #> $content$description #> [1] "ALK amplifications, fusions and mutations have been shown to be driving events in non-small cell lung cancer. 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#> $content$variants[[44]]$id #> [1] 2635 #> #> $content$variants[[44]]$evidence_items #> $content$variants[[44]]$evidence_items$accepted_count #> [1] 0 #> #> $content$variants[[44]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[44]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$variants[[45]] #> $content$variants[[45]]$name #> [1] "EML4-ALK C1156Y–L1196M" #> #> $content$variants[[45]]$id #> [1] 608 #> #> $content$variants[[45]]$evidence_items #> $content$variants[[45]]$evidence_items$accepted_count #> [1] 1 #> #> $content$variants[[45]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[45]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$variants[[46]] #> $content$variants[[46]]$name #> [1] "EML4-ALK T1151INST" #> #> $content$variants[[46]]$id #> [1] 173 #> #> $content$variants[[46]]$evidence_items #> $content$variants[[46]]$evidence_items$accepted_count #> [1] 4 #> #> $content$variants[[46]]$evidence_items$rejected_count #> [1] 0 #> #> $content$variants[[46]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> #> $content$aliases #> $content$aliases[[1]] #> [1] "ALK" #> #> $content$aliases[[2]] #> [1] "NBLST3" #> #> $content$aliases[[3]] #> [1] "CD246" #> #> #> $content$type #> [1] "gene" #> #> $content$lifecycle_actions #> named list() #> #> $content$sources #> $content$sources[[1]] #> $content$sources[[1]]$id #> [1] 1 #> #> $content$sources[[1]]$name #> [1] "ALK inhibitors and advanced non-small cell lung cancer (review)." #> #> $content$sources[[1]]$citation #> [1] "Rossi et al., 2014, Int. J. Oncol." #> #> $content$sources[[1]]$citation_id #> [1] "24889366" #> #> $content$sources[[1]]$source_type #> [1] "PubMed" #> #> $content$sources[[1]]$asco_abstract_id #> NULL #> #> $content$sources[[1]]$source_url #> [1] "http://www.ncbi.nlm.nih.gov/pubmed/24889366" #> #> $content$sources[[1]]$open_access #> NULL #> #> $content$sources[[1]]$pmc_id #> NULL #> #> $content$sources[[1]]$publication_date #> $content$sources[[1]]$publication_date$year #> [1] 2014 #> #> $content$sources[[1]]$publication_date$month #> [1] 8 #> #> #> $content$sources[[1]]$journal #> [1] "Int. J. Oncol." #> #> $content$sources[[1]]$full_journal_title #> [1] "International journal of oncology" #> #> $content$sources[[1]]$status #> [1] "fully curated" #> #> $content$sources[[1]]$is_review #> [1] FALSE #> #> $content$sources[[1]]$clinical_trials #> list() #> #> #> $content$sources[[2]] #> $content$sources[[2]]$id #> [1] 2 #> #> $content$sources[[2]]$name #> [1] "ALK in lung cancer: past, present, and future." #> #> $content$sources[[2]]$citation #> [1] "Shaw et al., 2013, J. Clin. Oncol." #> #> $content$sources[[2]]$citation_id #> [1] "23401436" #> #> $content$sources[[2]]$source_type #> [1] "PubMed" #> #> $content$sources[[2]]$asco_abstract_id #> NULL #> #> $content$sources[[2]]$source_url #> [1] "http://www.ncbi.nlm.nih.gov/pubmed/23401436" #> #> $content$sources[[2]]$open_access #> [1] TRUE #> #> $content$sources[[2]]$pmc_id #> [1] "PMC4209068" #> #> $content$sources[[2]]$publication_date #> $content$sources[[2]]$publication_date$year #> [1] 2013 #> #> $content$sources[[2]]$publication_date$month #> [1] 3 #> #> $content$sources[[2]]$publication_date$day #> [1] 10 #> #> #> $content$sources[[2]]$journal #> [1] "J. Clin. Oncol." #> #> $content$sources[[2]]$full_journal_title #> [1] "Journal of clinical oncology : official journal of the American Society of Clinical Oncology" #> #> $content$sources[[2]]$status #> [1] "fully curated" #> #> $content$sources[[2]]$is_review #> [1] FALSE #> #> $content$sources[[2]]$clinical_trials #> list() #> #> #> #> $content$provisional_values #> named list() #> #> $content$errors #> named list() #> #> #> $url #> [1] "https://civicdb.org/api/genes/ALK" #> #> $response #> Response [https://civicdb.org/api/genes/ALK?identifier_type=entrez_symbol] #> Date: 2019-09-03 16:44 #> Status: 200 #> Content-Type: application/json; charset=utf-8 #> Size: 6.75 kB #> #> #> attr(,"class") #> [1] "civic_api"getGene(id = 238, identifier_type = "entrez_id")#> $content #> $content$id #> [1] 1 #> #> $content$name #> [1] "ALK" #> #> $content$entrez_id #> [1] 238 #> #> $content$description #> [1] "ALK amplifications, fusions and mutations have been shown to be driving events in non-small cell lung cancer. While crizontinib has demonstrated efficacy in treating the amplification, mutations in ALK have been shown to confer resistance to current tyrosine kinase inhibitors. 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