Get a specific assertion

Retrieve a specific assertion from the CIViC DB

getAssertion(id)

Arguments

id	Internal CIViC ID of the assertion of interest

Value

An S3 Object of type civic_api containing the content, url, and response

Examples

getAssertion(id = 1)
#> $content
#> $content$id
#> [1] 1
#> 
#> $content$type
#> [1] "assertion"
#> 
#> $content$name
#> [1] "AID1"
#> 
#> $content$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$gene
#> $content$gene$name
#> [1] "ERBB2"
#> 
#> $content$gene$id
#> [1] 20
#> 
#> 
#> $content$variant
#> $content$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$variant$id
#> [1] 18
#> 
#> 
#> $content$disease
#> $content$disease$id
#> [1] 368
#> 
#> $content$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$disease$doid
#> [1] "0060079"
#> 
#> $content$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$drugs
#> $content$drugs[[1]]
#> $content$drugs[[1]]$id
#> [1] 84
#> 
#> $content$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_direction
#> [1] "Supports"
#> 
#> $content$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_item_count
#> [1] 3
#> 
#> $content$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$status
#> [1] "rejected"
#> 
#> $content$open_change_count
#> [1] 0
#> 
#> $content$pending_evidence_count
#> [1] 0
#> 
#> $content$nccn_guideline
#> [1] "Breast Cancer"
#> 
#> $content$nccn_guideline_version
#> [1] "3.2017"
#> 
#> $content$amp_level
#> [1] "Tier I - Level A"
#> 
#> $content$evidence_items
#> $content$evidence_items[[1]]
#> $content$evidence_items[[1]]$id
#> [1] 1122
#> 
#> $content$evidence_items[[1]]$name
#> [1] "EID1122"
#> 
#> $content$evidence_items[[1]]$description
#> [1] "HERA was a Phase III trial assessing application of trastuzumab in an extended adjuvant setting.  Patients were HER2 positive with completely excised invasive BC, node positive or negative, and having undergone prior adjuvant or neo-adjuvant chemotherapy.  In the 3 arm study patients were given trastuzumab courses of 1 year, 2 years, or untreated.  At the first planned interim analysis, trastuzumab treatment for one year was compared with observation alone.  A significant difference in disease-free survival was seen with 220 DFS events out of 1693 in the observation arm versus 127 DFS events out of 1694 in the 1 year trastuzumab arm.  1 year adjuvant trastuzumab is currently the standard of care."
#> 
#> $content$evidence_items[[1]]$disease
#> $content$evidence_items[[1]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[1]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[1]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[1]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[1]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[1]]$drugs
#> $content$evidence_items[[1]]$drugs[[1]]
#> $content$evidence_items[[1]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[1]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[1]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[1]]$rating
#> [1] 4
#> 
#> $content$evidence_items[[1]]$evidence_level
#> [1] "A"
#> 
#> $content$evidence_items[[1]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[1]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[1]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[1]]$variant_origin
#> [1] "Somatic Mutation"
#> 
#> $content$evidence_items[[1]]$drug_interaction_type
#> NULL
#> 
#> $content$evidence_items[[1]]$status
#> [1] "accepted"
#> 
#> $content$evidence_items[[1]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[1]]$type
#> [1] "evidence"
#> 
#> $content$evidence_items[[1]]$source
#> $content$evidence_items[[1]]$source$id
#> [1] 777
#> 
#> $content$evidence_items[[1]]$source$name
#> [1] "Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer."
#> 
#> $content$evidence_items[[1]]$source$citation
#> [1] "Piccart-Gebhart et al., 2005, N. Engl. J. Med."
#> 
#> $content$evidence_items[[1]]$source$citation_id
#> [1] "16236737"
#> 
#> $content$evidence_items[[1]]$source$source_type
#> [1] "PubMed"
#> 
#> $content$evidence_items[[1]]$source$asco_abstract_id
#> NULL
#> 
#> $content$evidence_items[[1]]$source$source_url
#> [1] "http://www.ncbi.nlm.nih.gov/pubmed/16236737"
#> 
#> $content$evidence_items[[1]]$source$open_access
#> NULL
#> 
#> $content$evidence_items[[1]]$source$pmc_id
#> NULL
#> 
#> $content$evidence_items[[1]]$source$publication_date
#> $content$evidence_items[[1]]$source$publication_date$year
#> [1] 2005
#> 
#> $content$evidence_items[[1]]$source$publication_date$month
#> [1] 10
#> 
#> $content$evidence_items[[1]]$source$publication_date$day
#> [1] 20
#> 
#> 
#> $content$evidence_items[[1]]$source$journal
#> [1] "N. Engl. J. Med."
#> 
#> $content$evidence_items[[1]]$source$full_journal_title
#> [1] "The New England journal of medicine"
#> 
#> $content$evidence_items[[1]]$source$status
#> [1] "fully curated"
#> 
#> $content$evidence_items[[1]]$source$is_review
#> [1] FALSE
#> 
#> $content$evidence_items[[1]]$source$clinical_trials
#> list()
#> 
#> 
#> $content$evidence_items[[1]]$variant_id
#> [1] 306
#> 
#> $content$evidence_items[[1]]$phenotypes
#> list()
#> 
#> $content$evidence_items[[1]]$assertions
#> $content$evidence_items[[1]]$assertions[[1]]
#> $content$evidence_items[[1]]$assertions[[1]]$id
#> [1] 1
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$type
#> [1] "assertion"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$name
#> [1] "AID1"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$gene
#> $content$evidence_items[[1]]$assertions[[1]]$gene$name
#> [1] "ERBB2"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$gene$id
#> [1] 20
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$variant
#> $content$evidence_items[[1]]$assertions[[1]]$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$variant$id
#> [1] 18
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$disease
#> $content$evidence_items[[1]]$assertions[[1]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$drugs
#> $content$evidence_items[[1]]$assertions[[1]]$drugs[[1]]
#> $content$evidence_items[[1]]$assertions[[1]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$evidence_item_count
#> [1] 3
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$status
#> [1] "rejected"
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[1]]$assertions[[1]]$pending_evidence_count
#> [1] 0
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[2]]
#> $content$evidence_items[[1]]$assertions[[2]]$id
#> [1] 2
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$type
#> [1] "assertion"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$name
#> [1] "AID2"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$gene
#> $content$evidence_items[[1]]$assertions[[2]]$gene$name
#> [1] "ERBB2"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$gene$id
#> [1] 20
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$variant
#> $content$evidence_items[[1]]$assertions[[2]]$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$variant$id
#> [1] 18
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$disease
#> $content$evidence_items[[1]]$assertions[[2]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$drugs
#> $content$evidence_items[[1]]$assertions[[2]]$drugs[[1]]
#> $content$evidence_items[[1]]$assertions[[2]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$evidence_item_count
#> [1] 3
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$status
#> [1] "accepted"
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[1]]$assertions[[2]]$pending_evidence_count
#> [1] 0
#> 
#> 
#> 
#> $content$evidence_items[[1]]$errors
#> named list()
#> 
#> $content$evidence_items[[1]]$lifecycle_actions
#> $content$evidence_items[[1]]$lifecycle_actions$submitted
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$timestamp
#> [1] "2016-02-26T08:41:00.728Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$id
#> [1] 110
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$name
#> [1] "Arpad Danos"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$last_seen_at
#> [1] "2019-09-02T21:23:03.109Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$username
#> [1] "arpaddanos"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/45c2db32371a9f86e1f6190f57758d77.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$avatars
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/45c2db32371a9f86e1f6190f57758d77.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/45c2db32371a9f86e1f6190f57758d77.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/45c2db32371a9f86e1f6190f57758d77.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/45c2db32371a9f86e1f6190f57758d77.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$orcid
#> [1] "https://orcid.org/0000-0001-9815-2288"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$display_name
#> [1] "arpaddanos"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$created_at
#> [1] "2016-01-27T00:20:51.218Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$url
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$linkedin_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$bio
#> [1] "Dr. Danos is a Postdoctoral Researcher in the Griffith Lab, with research interests in developing data and knowledge models which can describe and give structure to clinical and preclinical cancer variant knowledge, and in developing standards to enable efficient trasnfer and communication of this information between groups who are generating and curating this data, as well as with the medical and research community at large, in order to address the curation bottleneck which has arisen with increasing incorporation of NGS technology into clinical as well as research contexts. Dr. Danos is also interested in elucidation of the regulatory structure of the genome, and the role of non-coding mutations in cancer."
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$country
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$profile_image
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$submitted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$timestamp
#> [1] "2017-11-01T11:40:09.927Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$id
#> [1] 418
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$name
#> [1] "Paul Roepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$last_seen_at
#> [1] "2019-06-20T12:06:27.584Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$username
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$role
#> [1] "curator"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$avatars
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$area_of_expertise
#> [1] "Clinical Scientist"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$orcid
#> [1] "0000-0003-1566-0258"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$display_name
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$created_at
#> [1] "2017-04-04T11:32:56.753Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$url
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$linkedin_profile
#> [1] "proepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$bio
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$country
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$country$id
#> [1] 142
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$country$iso
#> [1] "NL"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$country$name
#> [1] "Netherlands"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_modified$user$organization
#> named list()
#> 
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$timestamp
#> [1] "2017-12-04T15:42:23.750Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$id
#> [1] 179
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$name
#> [1] "Erica Barnell"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$last_seen_at
#> [1] "2019-08-28T17:08:45.741Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$username
#> [1] "ebarnell"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/b9800d871c67538acd31728e8f509c80.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$avatars
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/b9800d871c67538acd31728e8f509c80.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/b9800d871c67538acd31728e8f509c80.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/b9800d871c67538acd31728e8f509c80.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/b9800d871c67538acd31728e8f509c80.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$orcid
#> [1] "0000-0003-1631-1201"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$display_name
#> [1] "ebarnell"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$created_at
#> [1] "2016-07-06T14:48:11.341Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$url
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$twitter_handle
#> [1] "erica.barnell"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$linkedin_profile
#> [1] "https://www.linkedin.com/in/erica-barnell-72b16a60"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$bio
#> [1] "MD/PhD candidate at the Washington University School of Medicine with PhD in Molecular Genetics and Genomics. Thesis work being completed in the Griffith Lab at the McDonnell Genome Institute to advance bioinformatic tools in the precision oncology space. Co-founded and current Chief Science Officer at Geneoscopy LLC, which is a life-sciences start-up company that leverages eukaryotic biomarkers to noninvasively diagnose, assess, and treat gastrointestinal disease."
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$country
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$profile_image
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_reviewed$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$timestamp
#> [1] "2017-11-01T10:54:47.582Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$id
#> [1] 418
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$name
#> [1] "Paul Roepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$last_seen_at
#> [1] "2019-06-20T12:06:27.584Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$username
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$role
#> [1] "curator"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$avatars
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$area_of_expertise
#> [1] "Clinical Scientist"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$orcid
#> [1] "0000-0003-1566-0258"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$display_name
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$created_at
#> [1] "2017-04-04T11:32:56.753Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$url
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$linkedin_profile
#> [1] "proepman"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$bio
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$country
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$country$id
#> [1] 142
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$country$iso
#> [1] "NL"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$country$name
#> [1] "Netherlands"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$last_commented_on$user$organization
#> named list()
#> 
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$timestamp
#> [1] "2016-02-26T14:59:53.268Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$id
#> [1] 41
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$name
#> [1] "Nick Spies"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$last_seen_at
#> [1] "2019-01-20T03:51:36.969Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$username
#> [1] "NickSpies"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$avatars
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$orcid
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$display_name
#> [1] "NickSpies"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$created_at
#> [1] "2015-06-12T18:13:16.508Z"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$url
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$twitter_handle
#> [1] "@NickSpies13"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$linkedin_profile
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$bio
#> [1] "Nick Spies is a staff analyst at the McDonnell Genome Institute and an MD student at Washington University School of Medicine. He has made substantial contributions to the development of genome analysis tools and resources at the Genome Institute including the Drug-Gene Interaction Database. He is a founding member of the CIViC team, helping to define the CIViC data model, and a leading content curator and a feature development consultant."
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$country
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$profile_image
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[1]]$lifecycle_actions$accepted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> 
#> $content$evidence_items[[1]]$fields_with_pending_changes
#> named list()
#> 
#> $content$evidence_items[[1]]$gene_id
#> [1] 20
#> 
#> $content$evidence_items[[1]]$state_params
#> $content$evidence_items[[1]]$state_params$evidence_item
#> $content$evidence_items[[1]]$state_params$evidence_item$id
#> [1] 1122
#> 
#> $content$evidence_items[[1]]$state_params$evidence_item$name
#> [1] "EID1122"
#> 
#> 
#> $content$evidence_items[[1]]$state_params$variant
#> $content$evidence_items[[1]]$state_params$variant$id
#> [1] 306
#> 
#> $content$evidence_items[[1]]$state_params$variant$name
#> [1] "AMPLIFICATION"
#> 
#> 
#> $content$evidence_items[[1]]$state_params$gene
#> $content$evidence_items[[1]]$state_params$gene$id
#> [1] 20
#> 
#> $content$evidence_items[[1]]$state_params$gene$name
#> [1] "ERBB2"
#> 
#> 
#> 
#> 
#> $content$evidence_items[[2]]
#> $content$evidence_items[[2]]$id
#> [1] 529
#> 
#> $content$evidence_items[[2]]$name
#> [1] "EID529"
#> 
#> $content$evidence_items[[2]]$description
#> [1] "A randomized clinical trial of 186 patients with previously untreated, HER2-positive, metastatic breast cancer demonstrated improved overall survival, response rate, response duration, time to progression, and time to treatment failure for patients who received trastuzumab in addition to chemotherapy (docetaxel) compared to chemotherapy alone."
#> 
#> $content$evidence_items[[2]]$disease
#> $content$evidence_items[[2]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[2]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[2]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[2]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[2]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[2]]$drugs
#> $content$evidence_items[[2]]$drugs[[1]]
#> $content$evidence_items[[2]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[2]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[2]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[2]]$rating
#> [1] 5
#> 
#> $content$evidence_items[[2]]$evidence_level
#> [1] "B"
#> 
#> $content$evidence_items[[2]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[2]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[2]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[2]]$variant_origin
#> [1] "Somatic Mutation"
#> 
#> $content$evidence_items[[2]]$drug_interaction_type
#> NULL
#> 
#> $content$evidence_items[[2]]$status
#> [1] "accepted"
#> 
#> $content$evidence_items[[2]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[2]]$type
#> [1] "evidence"
#> 
#> $content$evidence_items[[2]]$source
#> $content$evidence_items[[2]]$source$id
#> [1] 329
#> 
#> $content$evidence_items[[2]]$source$name
#> [1] "Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group."
#> 
#> $content$evidence_items[[2]]$source$citation
#> [1] "Marty et al., 2005, J. Clin. Oncol."
#> 
#> $content$evidence_items[[2]]$source$citation_id
#> [1] "15911866"
#> 
#> $content$evidence_items[[2]]$source$source_type
#> [1] "PubMed"
#> 
#> $content$evidence_items[[2]]$source$asco_abstract_id
#> NULL
#> 
#> $content$evidence_items[[2]]$source$source_url
#> [1] "http://www.ncbi.nlm.nih.gov/pubmed/15911866"
#> 
#> $content$evidence_items[[2]]$source$open_access
#> NULL
#> 
#> $content$evidence_items[[2]]$source$pmc_id
#> NULL
#> 
#> $content$evidence_items[[2]]$source$publication_date
#> $content$evidence_items[[2]]$source$publication_date$year
#> [1] 2005
#> 
#> $content$evidence_items[[2]]$source$publication_date$month
#> [1] 7
#> 
#> $content$evidence_items[[2]]$source$publication_date$day
#> [1] 1
#> 
#> 
#> $content$evidence_items[[2]]$source$journal
#> [1] "J. Clin. Oncol."
#> 
#> $content$evidence_items[[2]]$source$full_journal_title
#> [1] "Journal of clinical oncology : official journal of the American Society of Clinical Oncology"
#> 
#> $content$evidence_items[[2]]$source$status
#> [1] "fully curated"
#> 
#> $content$evidence_items[[2]]$source$is_review
#> [1] FALSE
#> 
#> $content$evidence_items[[2]]$source$clinical_trials
#> list()
#> 
#> 
#> $content$evidence_items[[2]]$variant_id
#> [1] 306
#> 
#> $content$evidence_items[[2]]$phenotypes
#> list()
#> 
#> $content$evidence_items[[2]]$assertions
#> $content$evidence_items[[2]]$assertions[[1]]
#> $content$evidence_items[[2]]$assertions[[1]]$id
#> [1] 1
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$type
#> [1] "assertion"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$name
#> [1] "AID1"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$gene
#> $content$evidence_items[[2]]$assertions[[1]]$gene$name
#> [1] "ERBB2"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$gene$id
#> [1] 20
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$variant
#> $content$evidence_items[[2]]$assertions[[1]]$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$variant$id
#> [1] 18
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$disease
#> $content$evidence_items[[2]]$assertions[[1]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$drugs
#> $content$evidence_items[[2]]$assertions[[1]]$drugs[[1]]
#> $content$evidence_items[[2]]$assertions[[1]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$evidence_item_count
#> [1] 3
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$status
#> [1] "rejected"
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[2]]$assertions[[1]]$pending_evidence_count
#> [1] 0
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[2]]
#> $content$evidence_items[[2]]$assertions[[2]]$id
#> [1] 2
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$type
#> [1] "assertion"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$name
#> [1] "AID2"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$gene
#> $content$evidence_items[[2]]$assertions[[2]]$gene$name
#> [1] "ERBB2"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$gene$id
#> [1] 20
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$variant
#> $content$evidence_items[[2]]$assertions[[2]]$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$variant$id
#> [1] 18
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$disease
#> $content$evidence_items[[2]]$assertions[[2]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$drugs
#> $content$evidence_items[[2]]$assertions[[2]]$drugs[[1]]
#> $content$evidence_items[[2]]$assertions[[2]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$evidence_item_count
#> [1] 3
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$status
#> [1] "accepted"
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[2]]$assertions[[2]]$pending_evidence_count
#> [1] 0
#> 
#> 
#> 
#> $content$evidence_items[[2]]$errors
#> named list()
#> 
#> $content$evidence_items[[2]]$lifecycle_actions
#> $content$evidence_items[[2]]$lifecycle_actions$submitted
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$timestamp
#> [1] "2015-08-25T16:20:01.514Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$id
#> [1] 3
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$name
#> [1] "Obi Griffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$username
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$avatars
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$display_name
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$url
#> [1] "http://genome.wustl.edu/people/individual/obi-griffith/"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$twitter_handle
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$country
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$profile_image
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$submitted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$timestamp
#> [1] "2017-11-01T11:42:05.451Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$id
#> [1] 418
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$name
#> [1] "Paul Roepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$last_seen_at
#> [1] "2019-06-20T12:06:27.584Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$username
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$role
#> [1] "curator"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$avatars
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$area_of_expertise
#> [1] "Clinical Scientist"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$orcid
#> [1] "0000-0003-1566-0258"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$display_name
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$created_at
#> [1] "2017-04-04T11:32:56.753Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$url
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$linkedin_profile
#> [1] "proepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$bio
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$country
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$country$id
#> [1] 142
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$country$iso
#> [1] "NL"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$country$name
#> [1] "Netherlands"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_modified$user$organization
#> named list()
#> 
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$timestamp
#> [1] "2018-01-11T18:48:23.019Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$id
#> [1] 3
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$name
#> [1] "Obi Griffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$username
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$avatars
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$display_name
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$url
#> [1] "http://genome.wustl.edu/people/individual/obi-griffith/"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$twitter_handle
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$country
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$profile_image
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_reviewed$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$timestamp
#> [1] "2017-11-01T10:55:46.360Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$id
#> [1] 418
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$name
#> [1] "Paul Roepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$last_seen_at
#> [1] "2019-06-20T12:06:27.584Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$username
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$role
#> [1] "curator"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$avatars
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$area_of_expertise
#> [1] "Clinical Scientist"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$orcid
#> [1] "0000-0003-1566-0258"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$display_name
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$created_at
#> [1] "2017-04-04T11:32:56.753Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$url
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$linkedin_profile
#> [1] "proepman"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$bio
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$country
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$country$id
#> [1] 142
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$country$iso
#> [1] "NL"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$country$name
#> [1] "Netherlands"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$last_commented_on$user$organization
#> named list()
#> 
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$timestamp
#> [1] "2015-08-25T16:20:01.514Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$id
#> [1] 41
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$name
#> [1] "Nick Spies"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$last_seen_at
#> [1] "2019-01-20T03:51:36.969Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$username
#> [1] "NickSpies"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$avatars
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$orcid
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$display_name
#> [1] "NickSpies"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$created_at
#> [1] "2015-06-12T18:13:16.508Z"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$url
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$twitter_handle
#> [1] "@NickSpies13"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$linkedin_profile
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$bio
#> [1] "Nick Spies is a staff analyst at the McDonnell Genome Institute and an MD student at Washington University School of Medicine. He has made substantial contributions to the development of genome analysis tools and resources at the Genome Institute including the Drug-Gene Interaction Database. He is a founding member of the CIViC team, helping to define the CIViC data model, and a leading content curator and a feature development consultant."
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$country
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$profile_image
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[2]]$lifecycle_actions$accepted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> 
#> $content$evidence_items[[2]]$fields_with_pending_changes
#> named list()
#> 
#> $content$evidence_items[[2]]$gene_id
#> [1] 20
#> 
#> $content$evidence_items[[2]]$state_params
#> $content$evidence_items[[2]]$state_params$evidence_item
#> $content$evidence_items[[2]]$state_params$evidence_item$id
#> [1] 529
#> 
#> $content$evidence_items[[2]]$state_params$evidence_item$name
#> [1] "EID529"
#> 
#> 
#> $content$evidence_items[[2]]$state_params$variant
#> $content$evidence_items[[2]]$state_params$variant$id
#> [1] 306
#> 
#> $content$evidence_items[[2]]$state_params$variant$name
#> [1] "AMPLIFICATION"
#> 
#> 
#> $content$evidence_items[[2]]$state_params$gene
#> $content$evidence_items[[2]]$state_params$gene$id
#> [1] 20
#> 
#> $content$evidence_items[[2]]$state_params$gene$name
#> [1] "ERBB2"
#> 
#> 
#> 
#> 
#> $content$evidence_items[[3]]
#> $content$evidence_items[[3]]$id
#> [1] 528
#> 
#> $content$evidence_items[[3]]$name
#> [1] "EID528"
#> 
#> $content$evidence_items[[3]]$description
#> [1] "A randomized clinical trial of 469 patients with previously untreated, HER2-positive, metastatic breast cancer demonstrated improved time to disease progression, objective response rate, and duration of response for patients who received trastuzumab in addition to chemotherapy compared to chemotherapy alone."
#> 
#> $content$evidence_items[[3]]$disease
#> $content$evidence_items[[3]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[3]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[3]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[3]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[3]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[3]]$drugs
#> $content$evidence_items[[3]]$drugs[[1]]
#> $content$evidence_items[[3]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[3]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[3]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[3]]$rating
#> [1] 5
#> 
#> $content$evidence_items[[3]]$evidence_level
#> [1] "B"
#> 
#> $content$evidence_items[[3]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[3]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[3]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[3]]$variant_origin
#> [1] "Somatic Mutation"
#> 
#> $content$evidence_items[[3]]$drug_interaction_type
#> NULL
#> 
#> $content$evidence_items[[3]]$status
#> [1] "accepted"
#> 
#> $content$evidence_items[[3]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[3]]$type
#> [1] "evidence"
#> 
#> $content$evidence_items[[3]]$source
#> $content$evidence_items[[3]]$source$id
#> [1] 328
#> 
#> $content$evidence_items[[3]]$source$name
#> [1] "Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2."
#> 
#> $content$evidence_items[[3]]$source$citation
#> [1] "Slamon et al., 2001, N. Engl. J. Med."
#> 
#> $content$evidence_items[[3]]$source$citation_id
#> [1] "11248153"
#> 
#> $content$evidence_items[[3]]$source$source_type
#> [1] "PubMed"
#> 
#> $content$evidence_items[[3]]$source$asco_abstract_id
#> NULL
#> 
#> $content$evidence_items[[3]]$source$source_url
#> [1] "http://www.ncbi.nlm.nih.gov/pubmed/11248153"
#> 
#> $content$evidence_items[[3]]$source$open_access
#> NULL
#> 
#> $content$evidence_items[[3]]$source$pmc_id
#> NULL
#> 
#> $content$evidence_items[[3]]$source$publication_date
#> $content$evidence_items[[3]]$source$publication_date$year
#> [1] 2001
#> 
#> $content$evidence_items[[3]]$source$publication_date$month
#> [1] 3
#> 
#> $content$evidence_items[[3]]$source$publication_date$day
#> [1] 15
#> 
#> 
#> $content$evidence_items[[3]]$source$journal
#> [1] "N. Engl. J. Med."
#> 
#> $content$evidence_items[[3]]$source$full_journal_title
#> [1] "The New England journal of medicine"
#> 
#> $content$evidence_items[[3]]$source$status
#> [1] "fully curated"
#> 
#> $content$evidence_items[[3]]$source$is_review
#> [1] FALSE
#> 
#> $content$evidence_items[[3]]$source$clinical_trials
#> list()
#> 
#> 
#> $content$evidence_items[[3]]$variant_id
#> [1] 306
#> 
#> $content$evidence_items[[3]]$phenotypes
#> list()
#> 
#> $content$evidence_items[[3]]$assertions
#> $content$evidence_items[[3]]$assertions[[1]]
#> $content$evidence_items[[3]]$assertions[[1]]$id
#> [1] 1
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$type
#> [1] "assertion"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$name
#> [1] "AID1"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$gene
#> $content$evidence_items[[3]]$assertions[[1]]$gene$name
#> [1] "ERBB2"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$gene$id
#> [1] 20
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$variant
#> $content$evidence_items[[3]]$assertions[[1]]$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$variant$id
#> [1] 18
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$disease
#> $content$evidence_items[[3]]$assertions[[1]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$drugs
#> $content$evidence_items[[3]]$assertions[[1]]$drugs[[1]]
#> $content$evidence_items[[3]]$assertions[[1]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$evidence_item_count
#> [1] 3
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$status
#> [1] "rejected"
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[3]]$assertions[[1]]$pending_evidence_count
#> [1] 0
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[2]]
#> $content$evidence_items[[3]]$assertions[[2]]$id
#> [1] 2
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$type
#> [1] "assertion"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$name
#> [1] "AID2"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$summary
#> [1] "HER2 amplification predicts sensitivity to Trastuzumab"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$description
#> [1] "HER2 amplification defines a clinically relevant subtype of breast cancer. HER2 amplification predicts sensitivity to various targeted therapies including the monoclonal antibody Trastuzumab. The use of Trastuzumab, often in combination with chemotherapy and/or endocrine therapy (depending on hormone receptor status), is now standard of care for HER2-positive breast cancer patients."
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$gene
#> $content$evidence_items[[3]]$assertions[[2]]$gene$name
#> [1] "ERBB2"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$gene$id
#> [1] 20
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$variant
#> $content$evidence_items[[3]]$assertions[[2]]$variant$name
#> [1] "AMPLIFICATION"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$variant$id
#> [1] 18
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$disease
#> $content$evidence_items[[3]]$assertions[[2]]$disease$id
#> [1] 368
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$disease$name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$disease$display_name
#> [1] "Her2-receptor Positive Breast Cancer"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$disease$doid
#> [1] "0060079"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$disease$url
#> [1] "http://www.disease-ontology.org/?id=DOID:0060079"
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$drugs
#> $content$evidence_items[[3]]$assertions[[2]]$drugs[[1]]
#> $content$evidence_items[[3]]$assertions[[2]]$drugs[[1]]$id
#> [1] 84
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$drugs[[1]]$name
#> [1] "Trastuzumab"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$drugs[[1]]$pubchem_id
#> NULL
#> 
#> 
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$evidence_type
#> [1] "Predictive"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$evidence_direction
#> [1] "Supports"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$clinical_significance
#> [1] "Sensitivity/Response"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$evidence_item_count
#> [1] 3
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$fda_regulatory_approval
#> [1] TRUE
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$status
#> [1] "accepted"
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$open_change_count
#> [1] 0
#> 
#> $content$evidence_items[[3]]$assertions[[2]]$pending_evidence_count
#> [1] 0
#> 
#> 
#> 
#> $content$evidence_items[[3]]$errors
#> named list()
#> 
#> $content$evidence_items[[3]]$lifecycle_actions
#> $content$evidence_items[[3]]$lifecycle_actions$submitted
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$timestamp
#> [1] "2015-08-25T15:42:25.527Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$id
#> [1] 3
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$name
#> [1] "Obi Griffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$username
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$avatars
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$display_name
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$url
#> [1] "http://genome.wustl.edu/people/individual/obi-griffith/"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$twitter_handle
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$country
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$profile_image
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$submitted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$timestamp
#> [1] "2017-11-01T11:41:27.713Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$id
#> [1] 418
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$name
#> [1] "Paul Roepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$last_seen_at
#> [1] "2019-06-20T12:06:27.584Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$username
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$role
#> [1] "curator"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$avatars
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$area_of_expertise
#> [1] "Clinical Scientist"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$orcid
#> [1] "0000-0003-1566-0258"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$display_name
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$created_at
#> [1] "2017-04-04T11:32:56.753Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$url
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$linkedin_profile
#> [1] "proepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$bio
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$country
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$country$id
#> [1] 142
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$country$iso
#> [1] "NL"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$country$name
#> [1] "Netherlands"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_modified$user$organization
#> named list()
#> 
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$timestamp
#> [1] "2018-01-11T18:47:57.238Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$id
#> [1] 3
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$name
#> [1] "Obi Griffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$username
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$avatars
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$display_name
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$url
#> [1] "http://genome.wustl.edu/people/individual/obi-griffith/"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$twitter_handle
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$country
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$profile_image
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_reviewed$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$timestamp
#> [1] "2017-11-01T10:55:28.039Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$id
#> [1] 418
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$name
#> [1] "Paul Roepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$last_seen_at
#> [1] "2019-06-20T12:06:27.584Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$username
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$role
#> [1] "curator"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$avatars
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/5e89a792925cb4b4e355c11a7b6c253d.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$area_of_expertise
#> [1] "Clinical Scientist"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$orcid
#> [1] "0000-0003-1566-0258"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$display_name
#> [1] "PaulRoepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$created_at
#> [1] "2017-04-04T11:32:56.753Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$url
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$twitter_handle
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$linkedin_profile
#> [1] "proepman"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$bio
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$country
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$country$id
#> [1] 142
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$country$iso
#> [1] "NL"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$country$name
#> [1] "Netherlands"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$featured_expert
#> [1] FALSE
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$last_commented_on$user$organization
#> named list()
#> 
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$timestamp
#> [1] "2015-08-25T15:42:25.527Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$id
#> [1] 41
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$name
#> [1] "Nick Spies"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$last_seen_at
#> [1] "2019-01-20T03:51:36.969Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$username
#> [1] "NickSpies"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$role
#> [1] "admin"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$avatars
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=128"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=64"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=32"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/3376aeb8439c5ab3e5d72fa2eeed39e5.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$orcid
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$display_name
#> [1] "NickSpies"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$created_at
#> [1] "2015-06-12T18:13:16.508Z"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$url
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$twitter_handle
#> [1] "@NickSpies13"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$facebook_profile
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$linkedin_profile
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$bio
#> [1] "Nick Spies is a staff analyst at the McDonnell Genome Institute and an MD student at Washington University School of Medicine. He has made substantial contributions to the development of genome analysis tools and resources at the Genome Institute including the Drug-Gene Interaction Database. He is a founding member of the CIViC team, helping to define the CIViC data model, and a leading content curator and a feature development consultant."
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$country
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$country$id
#> [1] 214
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$country$iso
#> [1] "US"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$featured_expert
#> [1] TRUE
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$accepted_license
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$signup_complete
#> NULL
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$affiliation
#> [1] ""
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$id
#> [1] 1
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$profile_image
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$evidence_items[[3]]$lifecycle_actions$accepted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> 
#> $content$evidence_items[[3]]$fields_with_pending_changes
#> named list()
#> 
#> $content$evidence_items[[3]]$gene_id
#> [1] 20
#> 
#> $content$evidence_items[[3]]$state_params
#> $content$evidence_items[[3]]$state_params$evidence_item
#> $content$evidence_items[[3]]$state_params$evidence_item$id
#> [1] 528
#> 
#> $content$evidence_items[[3]]$state_params$evidence_item$name
#> [1] "EID528"
#> 
#> 
#> $content$evidence_items[[3]]$state_params$variant
#> $content$evidence_items[[3]]$state_params$variant$id
#> [1] 306
#> 
#> $content$evidence_items[[3]]$state_params$variant$name
#> [1] "AMPLIFICATION"
#> 
#> 
#> $content$evidence_items[[3]]$state_params$gene
#> $content$evidence_items[[3]]$state_params$gene$id
#> [1] 20
#> 
#> $content$evidence_items[[3]]$state_params$gene$name
#> [1] "ERBB2"
#> 
#> 
#> 
#> 
#> 
#> $content$acmg_codes
#> list()
#> 
#> $content$drug_interaction_type
#> NULL
#> 
#> $content$fda_companion_test
#> [1] TRUE
#> 
#> $content$allele_registry_id
#> NULL
#> 
#> $content$phenotypes
#> list()
#> 
#> $content$variant_origin
#> [1] "Somatic Mutation"
#> 
#> $content$lifecycle_actions
#> $content$lifecycle_actions$submitted
#> $content$lifecycle_actions$submitted$timestamp
#> [1] "2018-01-11T18:47:27.967Z"
#> 
#> $content$lifecycle_actions$submitted$user
#> $content$lifecycle_actions$submitted$user$id
#> [1] 3
#> 
#> $content$lifecycle_actions$submitted$user$name
#> [1] "Obi Griffith"
#> 
#> $content$lifecycle_actions$submitted$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$lifecycle_actions$submitted$user$username
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$submitted$user$role
#> [1] "admin"
#> 
#> $content$lifecycle_actions$submitted$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$submitted$user$avatars
#> $content$lifecycle_actions$submitted$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$lifecycle_actions$submitted$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
#> 
#> $content$lifecycle_actions$submitted$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$submitted$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$lifecycle_actions$submitted$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$lifecycle_actions$submitted$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$lifecycle_actions$submitted$user$display_name
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$submitted$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$lifecycle_actions$submitted$user$url
#> [1] "http://genome.wustl.edu/people/individual/obi-griffith/"
#> 
#> $content$lifecycle_actions$submitted$user$twitter_handle
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$submitted$user$facebook_profile
#> [1] ""
#> 
#> $content$lifecycle_actions$submitted$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$submitted$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$lifecycle_actions$submitted$user$country
#> $content$lifecycle_actions$submitted$user$country$id
#> [1] 214
#> 
#> $content$lifecycle_actions$submitted$user$country$iso
#> [1] "US"
#> 
#> $content$lifecycle_actions$submitted$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$lifecycle_actions$submitted$user$featured_expert
#> [1] TRUE
#> 
#> $content$lifecycle_actions$submitted$user$accepted_license
#> NULL
#> 
#> $content$lifecycle_actions$submitted$user$signup_complete
#> NULL
#> 
#> $content$lifecycle_actions$submitted$user$affiliation
#> [1] ""
#> 
#> $content$lifecycle_actions$submitted$user$organization
#> $content$lifecycle_actions$submitted$user$organization$id
#> [1] 1
#> 
#> $content$lifecycle_actions$submitted$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$lifecycle_actions$submitted$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$lifecycle_actions$submitted$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$lifecycle_actions$submitted$user$organization$profile_image
#> $content$lifecycle_actions$submitted$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$submitted$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$submitted$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$submitted$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$submitted$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$lifecycle_actions$submitted$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$lifecycle_actions$last_modified
#> $content$lifecycle_actions$last_modified$timestamp
#> [1] "2019-05-22T15:47:05.697Z"
#> 
#> $content$lifecycle_actions$last_modified$user
#> $content$lifecycle_actions$last_modified$user$id
#> [1] 3
#> 
#> $content$lifecycle_actions$last_modified$user$name
#> [1] "Obi Griffith"
#> 
#> $content$lifecycle_actions$last_modified$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$lifecycle_actions$last_modified$user$username
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$last_modified$user$role
#> [1] "admin"
#> 
#> $content$lifecycle_actions$last_modified$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$last_modified$user$avatars
#> $content$lifecycle_actions$last_modified$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$lifecycle_actions$last_modified$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
#> 
#> $content$lifecycle_actions$last_modified$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$last_modified$user$avatars$x14
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=14"
#> 
#> 
#> $content$lifecycle_actions$last_modified$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$lifecycle_actions$last_modified$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$lifecycle_actions$last_modified$user$display_name
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$last_modified$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$lifecycle_actions$last_modified$user$url
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#> 
#> $content$lifecycle_actions$last_modified$user$twitter_handle
#> [1] "obigriffith"
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#> $content$lifecycle_actions$last_modified$user$facebook_profile
#> [1] ""
#> 
#> $content$lifecycle_actions$last_modified$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$last_modified$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$lifecycle_actions$last_modified$user$country
#> $content$lifecycle_actions$last_modified$user$country$id
#> [1] 214
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#> $content$lifecycle_actions$last_modified$user$country$iso
#> [1] "US"
#> 
#> $content$lifecycle_actions$last_modified$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$lifecycle_actions$last_modified$user$featured_expert
#> [1] TRUE
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#> $content$lifecycle_actions$last_modified$user$accepted_license
#> NULL
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#> $content$lifecycle_actions$last_modified$user$signup_complete
#> NULL
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#> $content$lifecycle_actions$last_modified$user$affiliation
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#> $content$lifecycle_actions$last_modified$user$organization
#> $content$lifecycle_actions$last_modified$user$organization$id
#> [1] 1
#> 
#> $content$lifecycle_actions$last_modified$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$lifecycle_actions$last_modified$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$lifecycle_actions$last_modified$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$lifecycle_actions$last_modified$user$organization$profile_image
#> $content$lifecycle_actions$last_modified$user$organization$profile_image$x256
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#> 
#> $content$lifecycle_actions$last_modified$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$last_modified$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$last_modified$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$last_modified$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$lifecycle_actions$last_modified$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$lifecycle_actions$last_reviewed
#> $content$lifecycle_actions$last_reviewed$timestamp
#> [1] "2019-05-22T15:47:35.415Z"
#> 
#> $content$lifecycle_actions$last_reviewed$user
#> $content$lifecycle_actions$last_reviewed$user$id
#> [1] 15
#> 
#> $content$lifecycle_actions$last_reviewed$user$name
#> [1] "Malachi Griffith"
#> 
#> $content$lifecycle_actions$last_reviewed$user$last_seen_at
#> [1] "2019-08-29T20:56:30.703Z"
#> 
#> $content$lifecycle_actions$last_reviewed$user$username
#> [1] "MalachiGriffith"
#> 
#> $content$lifecycle_actions$last_reviewed$user$role
#> [1] "admin"
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#> [1] "https://secure.gravatar.com/avatar/a4d9fc3b05d58cf3d3ba51dc30bb61d6.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$last_reviewed$user$avatars
#> $content$lifecycle_actions$last_reviewed$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/a4d9fc3b05d58cf3d3ba51dc30bb61d6.png?d=identicon&r=pg&s=128"
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#> [1] "https://secure.gravatar.com/avatar/a4d9fc3b05d58cf3d3ba51dc30bb61d6.png?d=identicon&r=pg&s=64"
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#> 
#> 
#> $content$lifecycle_actions$last_reviewed$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$lifecycle_actions$last_reviewed$user$orcid
#> [1] "0000-0002-6388-446X"
#> 
#> $content$lifecycle_actions$last_reviewed$user$display_name
#> [1] "MalachiGriffith"
#> 
#> $content$lifecycle_actions$last_reviewed$user$created_at
#> [1] "2015-02-26T22:25:34.692Z"
#> 
#> $content$lifecycle_actions$last_reviewed$user$url
#> [1] "http://genome.wustl.edu/people/individual/malachi-griffith/"
#> 
#> $content$lifecycle_actions$last_reviewed$user$twitter_handle
#> [1] "malachigriffith"
#> 
#> $content$lifecycle_actions$last_reviewed$user$facebook_profile
#> [1] ""
#> 
#> $content$lifecycle_actions$last_reviewed$user$linkedin_profile
#> [1] "malachigriffith"
#> 
#> $content$lifecycle_actions$last_reviewed$user$bio
#> [1] "Dr. Griffith is an Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. Dr Griffith has extensive experience in the fields of genomics, bioinformatics, data mining, and cancer research. His research is focused on improving the understanding of cancer biology and the development of personalized medicine strategies for cancer using genomics and informatics technologies. The Griffith lab develops bioinformatics and statistical methods for the analysis of high throughput sequence data and identification of biomarkers for diagnostic, prognostic and drug response prediction. The Griffith lab uses CIViC to interpret variants identified in cases examined by the WASHU Genomics Tumor Board. He is a co-creator of the CIViC resource."
#> 
#> $content$lifecycle_actions$last_reviewed$user$country
#> $content$lifecycle_actions$last_reviewed$user$country$id
#> [1] 214
#> 
#> $content$lifecycle_actions$last_reviewed$user$country$iso
#> [1] "US"
#> 
#> $content$lifecycle_actions$last_reviewed$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$lifecycle_actions$last_reviewed$user$featured_expert
#> [1] TRUE
#> 
#> $content$lifecycle_actions$last_reviewed$user$accepted_license
#> NULL
#> 
#> $content$lifecycle_actions$last_reviewed$user$signup_complete
#> NULL
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#> $content$lifecycle_actions$last_reviewed$user$affiliation
#> [1] ""
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization
#> $content$lifecycle_actions$last_reviewed$user$organization$id
#> [1] 1
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$profile_image
#> $content$lifecycle_actions$last_reviewed$user$organization$profile_image$x256
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#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$lifecycle_actions$last_reviewed$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> $content$lifecycle_actions$rejected
#> $content$lifecycle_actions$rejected$timestamp
#> [1] "2018-01-11T19:20:55.033Z"
#> 
#> $content$lifecycle_actions$rejected$user
#> $content$lifecycle_actions$rejected$user$id
#> [1] 3
#> 
#> $content$lifecycle_actions$rejected$user$name
#> [1] "Obi Griffith"
#> 
#> $content$lifecycle_actions$rejected$user$last_seen_at
#> [1] "2019-08-26T20:34:15.034Z"
#> 
#> $content$lifecycle_actions$rejected$user$username
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$rejected$user$role
#> [1] "admin"
#> 
#> $content$lifecycle_actions$rejected$user$avatar_url
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$rejected$user$avatars
#> $content$lifecycle_actions$rejected$user$avatars$x128
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=128"
#> 
#> $content$lifecycle_actions$rejected$user$avatars$x64
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=64"
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#> $content$lifecycle_actions$rejected$user$avatars$x32
#> [1] "https://secure.gravatar.com/avatar/4c468e9a95d6135e02eb66ee5f2fb574.png?d=identicon&r=pg&s=32"
#> 
#> $content$lifecycle_actions$rejected$user$avatars$x14
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#> 
#> 
#> $content$lifecycle_actions$rejected$user$area_of_expertise
#> [1] "Research Scientist"
#> 
#> $content$lifecycle_actions$rejected$user$orcid
#> [1] "0000-0002-0843-4271"
#> 
#> $content$lifecycle_actions$rejected$user$display_name
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$rejected$user$created_at
#> [1] "2015-02-26T02:53:49.147Z"
#> 
#> $content$lifecycle_actions$rejected$user$url
#> [1] "http://genome.wustl.edu/people/individual/obi-griffith/"
#> 
#> $content$lifecycle_actions$rejected$user$twitter_handle
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$rejected$user$facebook_profile
#> [1] ""
#> 
#> $content$lifecycle_actions$rejected$user$linkedin_profile
#> [1] "obigriffith"
#> 
#> $content$lifecycle_actions$rejected$user$bio
#> [1] "Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has worked in genomics and bioinformatics since the earliest phase of reference genome sequencing. He contributed to the Mammalian Gene Collection, producing some of the first full-length sequences for many human genes. He also was part of a small team of bioinformaticians that helped sequence and release the first whole genome reference sequence for the severe acute respiratory syndrome (SARS) virus at the height of the 2003 epidemic. He has contributed to the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis and prognosis of thyroid, breast, lymphoma and other cancers. His lab’s research is focused on the development of informatics resources and personalized medicine strategies for cancer using genomic technologies. He is a co-creator of the CIViC resource."
#> 
#> $content$lifecycle_actions$rejected$user$country
#> $content$lifecycle_actions$rejected$user$country$id
#> [1] 214
#> 
#> $content$lifecycle_actions$rejected$user$country$iso
#> [1] "US"
#> 
#> $content$lifecycle_actions$rejected$user$country$name
#> [1] "United States"
#> 
#> 
#> $content$lifecycle_actions$rejected$user$featured_expert
#> [1] TRUE
#> 
#> $content$lifecycle_actions$rejected$user$accepted_license
#> NULL
#> 
#> $content$lifecycle_actions$rejected$user$signup_complete
#> NULL
#> 
#> $content$lifecycle_actions$rejected$user$affiliation
#> [1] ""
#> 
#> $content$lifecycle_actions$rejected$user$organization
#> $content$lifecycle_actions$rejected$user$organization$id
#> [1] 1
#> 
#> $content$lifecycle_actions$rejected$user$organization$name
#> [1] "The McDonnell Genome Institute"
#> 
#> $content$lifecycle_actions$rejected$user$organization$url
#> [1] "http://genome.wustl.edu/"
#> 
#> $content$lifecycle_actions$rejected$user$organization$description
#> [1] "The McDonnell Genome Institute (MGI) is a world leader in the fast-paced, constantly changing field of genomics. A truly unique institution, we are pushing the limits of academic research by creating, testing, and implementing new approaches to the study of biology with the goal of understanding human health and disease, as well as evolution and the biology of other organisms."
#> 
#> $content$lifecycle_actions$rejected$user$organization$profile_image
#> $content$lifecycle_actions$rejected$user$organization$profile_image$x256
#> [1] "/system/organizations/profile_images/000/000/001/x256/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$rejected$user$organization$profile_image$x128
#> [1] "/system/organizations/profile_images/000/000/001/x128/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$rejected$user$organization$profile_image$x64
#> [1] "/system/organizations/profile_images/000/000/001/x64/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$rejected$user$organization$profile_image$x32
#> [1] "/system/organizations/profile_images/000/000/001/x32/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> $content$lifecycle_actions$rejected$user$organization$profile_image$x14
#> [1] "/system/organizations/profile_images/000/000/001/x14/MGI_STANDARD4_logo_brown-example_v1b.png?1494525976"
#> 
#> 
#> $content$lifecycle_actions$rejected$user$organization$parent
#> named list()
#> 
#> 
#> 
#> 
#> 
#> $content$provisional_values
#> named list()
#> 
#> $content$errors
#> named list()
#> 
#> 
#> $url
#> [1] "https://civicdb.org/api/assertions/1"
#> 
#> $response
#> Response [https://civicdb.org/api/assertions/1]
#>   Date: 2019-09-03 16:44
#>   Status: 200
#>   Content-Type: application/json; charset=utf-8
#>   Size: 60 kB
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#> 
#> attr(,"class")
#> [1] "civic_api"