getAllGenes.RdRetrieve all genes from the CIViC DB
getAllGenes(page = 1, count = 25)
| page | the page number to retrieve |
|---|---|
| count | the number of genes to retrieve |
An S3 Object of type civic_api containing the content, url, and response
getAllGenes(count = 10)#> $content #> $content$`_meta` #> $content$`_meta`$current_page #> [1] 1 #> #> $content$`_meta`$per_page #> [1] "10" #> #> $content$`_meta`$total_pages #> [1] 32 #> #> $content$`_meta`$total_count #> [1] 313 #> #> $content$`_meta`$links #> $content$`_meta`$links$`next` #> [1] "https://civicdb.org/api/genes?count=10&page=2" #> #> $content$`_meta`$links$previous #> NULL #> #> #> #> $content$records #> $content$records[[1]] #> $content$records[[1]]$id #> [1] 1 #> #> $content$records[[1]]$name #> [1] "ALK" #> #> $content$records[[1]]$entrez_id #> [1] 238 #> #> $content$records[[1]]$description #> [1] "ALK amplifications, fusions and mutations have been shown to be driving events in non-small cell lung cancer. While crizontinib has demonstrated efficacy in treating the amplification, mutations in ALK have been shown to confer resistance to current tyrosine kinase inhibitors. Second-generation TKI's have seen varied success in treating these resistant cases, and the HSP90 inhibitor 17-AAG has been shown to be cytostatic in ALK-altered cell lines." #> #> $content$records[[1]]$variants #> $content$records[[1]]$variants[[1]] #> $content$records[[1]]$variants[[1]]$name #> [1] "EML4-ALK T1151INST" #> #> $content$records[[1]]$variants[[1]]$id #> [1] 173 #> #> $content$records[[1]]$variants[[1]]$evidence_items #> $content$records[[1]]$variants[[1]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[1]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[1]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[1]]$variants[[2]] #> $content$records[[1]]$variants[[2]]$name #> [1] "EML4-ALK C1156Y–L1196M" #> #> $content$records[[1]]$variants[[2]]$id #> [1] 608 #> #> $content$records[[1]]$variants[[2]]$evidence_items #> $content$records[[1]]$variants[[2]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[3]] #> $content$records[[1]]$variants[[3]]$name #> [1] "EML4-ALK E20;A20" #> #> $content$records[[1]]$variants[[3]]$id #> [1] 500 #> #> $content$records[[1]]$variants[[3]]$evidence_items #> $content$records[[1]]$variants[[3]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[1]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[4]] #> $content$records[[1]]$variants[[4]]$name #> [1] "ALK FUSION" #> #> $content$records[[1]]$variants[[4]]$id #> [1] 2220 #> #> $content$records[[1]]$variants[[4]]$evidence_items #> $content$records[[1]]$variants[[4]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[4]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[5]] #> $content$records[[1]]$variants[[5]]$name #> [1] "EML4-ALK C1156Y" #> #> $content$records[[1]]$variants[[5]]$id #> [1] 6 #> #> $content$records[[1]]$variants[[5]]$evidence_items #> $content$records[[1]]$variants[[5]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[1]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[5]]$evidence_items$submitted_count #> [1] 5 #> #> #> #> $content$records[[1]]$variants[[6]] #> $content$records[[1]]$variants[[6]]$name #> [1] "MUTATION" #> #> $content$records[[1]]$variants[[6]]$id #> [1] 512 #> #> $content$records[[1]]$variants[[6]]$evidence_items #> $content$records[[1]]$variants[[6]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[6]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[7]] #> $content$records[[1]]$variants[[7]]$name #> [1] "DEL4-11" #> #> $content$records[[1]]$variants[[7]]$id #> [1] 550 #> #> $content$records[[1]]$variants[[7]]$evidence_items #> $content$records[[1]]$variants[[7]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[7]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[8]] #> $content$records[[1]]$variants[[8]]$name #> [1] "EML4-ALK V1180L" #> #> $content$records[[1]]$variants[[8]]$id #> [1] 528 #> #> $content$records[[1]]$variants[[8]]$evidence_items #> $content$records[[1]]$variants[[8]]$evidence_items$accepted_count #> [1] 5 #> #> $content$records[[1]]$variants[[8]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[8]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[9]] #> $content$records[[1]]$variants[[9]]$name #> [1] "F1245C" #> #> $content$records[[1]]$variants[[9]]$id #> [1] 549 #> #> $content$records[[1]]$variants[[9]]$evidence_items #> $content$records[[1]]$variants[[9]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[1]]$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[9]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[10]] #> $content$records[[1]]$variants[[10]]$name #> [1] "EML4-ALK L1196M" #> #> $content$records[[1]]$variants[[10]]$id #> [1] 7 #> #> $content$records[[1]]$variants[[10]]$evidence_items #> $content$records[[1]]$variants[[10]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[1]]$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[10]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[1]]$variants[[11]] #> $content$records[[1]]$variants[[11]]$name #> [1] "EML4-ALK G1269A" #> #> $content$records[[1]]$variants[[11]]$id #> [1] 308 #> #> $content$records[[1]]$variants[[11]]$evidence_items #> $content$records[[1]]$variants[[11]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[1]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[11]]$evidence_items$submitted_count #> [1] 5 #> #> #> #> $content$records[[1]]$variants[[12]] #> $content$records[[1]]$variants[[12]]$name #> [1] "ALK FUSION I1171" #> #> $content$records[[1]]$variants[[12]]$id #> [1] 527 #> #> $content$records[[1]]$variants[[12]]$evidence_items #> $content$records[[1]]$variants[[12]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[1]]$variants[[12]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[12]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[1]]$variants[[13]] #> $content$records[[1]]$variants[[13]]$name #> [1] "ALK FUSION G1202R" #> #> $content$records[[1]]$variants[[13]]$id #> [1] 171 #> #> $content$records[[1]]$variants[[13]]$evidence_items #> $content$records[[1]]$variants[[13]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[1]]$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[13]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[1]]$variants[[14]] #> $content$records[[1]]$variants[[14]]$name #> [1] "ALK FUSION G1269A" #> #> $content$records[[1]]$variants[[14]]$id #> [1] 552 #> #> $content$records[[1]]$variants[[14]]$evidence_items #> $content$records[[1]]$variants[[14]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[1]]$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[14]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[15]] #> $content$records[[1]]$variants[[15]]$name #> [1] "F1174L" #> #> $content$records[[1]]$variants[[15]]$id #> [1] 8 #> #> $content$records[[1]]$variants[[15]]$evidence_items #> $content$records[[1]]$variants[[15]]$evidence_items$accepted_count #> [1] 9 #> #> $content$records[[1]]$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[15]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[1]]$variants[[16]] #> $content$records[[1]]$variants[[16]]$name #> [1] "ALK FUSION F1245C" #> #> $content$records[[1]]$variants[[16]]$id #> [1] 551 #> #> $content$records[[1]]$variants[[16]]$evidence_items #> $content$records[[1]]$variants[[16]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[1]]$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[16]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[17]] #> $content$records[[1]]$variants[[17]]$name #> [1] "HIP1-ALK I1171N" #> #> $content$records[[1]]$variants[[17]]$id #> [1] 588 #> #> $content$records[[1]]$variants[[17]]$evidence_items #> $content$records[[1]]$variants[[17]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[17]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[1]]$variants[[18]] #> $content$records[[1]]$variants[[18]]$name #> [1] "NPM-ALK" #> #> $content$records[[1]]$variants[[18]]$id #> [1] 513 #> #> $content$records[[1]]$variants[[18]]$evidence_items #> $content$records[[1]]$variants[[18]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[1]]$variants[[18]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[1]]$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[19]] #> $content$records[[1]]$variants[[19]]$name #> [1] "EML4-ALK L1152R" #> #> $content$records[[1]]$variants[[19]]$id #> [1] 307 #> #> $content$records[[1]]$variants[[19]]$evidence_items #> $content$records[[1]]$variants[[19]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[19]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[19]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[20]] #> $content$records[[1]]$variants[[20]]$name #> [1] "EML4-ALK C1156Y–L1198F" #> #> $content$records[[1]]$variants[[20]]$id #> [1] 352 #> #> $content$records[[1]]$variants[[20]]$evidence_items #> $content$records[[1]]$variants[[20]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[1]]$variants[[20]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[20]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[21]] #> $content$records[[1]]$variants[[21]]$name #> [1] "ALK FUSIONS" #> #> $content$records[[1]]$variants[[21]]$id #> [1] 499 #> #> $content$records[[1]]$variants[[21]]$evidence_items #> $content$records[[1]]$variants[[21]]$evidence_items$accepted_count #> [1] 26 #> #> $content$records[[1]]$variants[[21]]$evidence_items$rejected_count #> [1] 2 #> #> $content$records[[1]]$variants[[21]]$evidence_items$submitted_count #> [1] 6 #> #> #> #> $content$records[[1]]$variants[[22]] #> $content$records[[1]]$variants[[22]]$name #> [1] "EML4-ALK I1171S" #> #> $content$records[[1]]$variants[[22]]$id #> [1] 589 #> #> $content$records[[1]]$variants[[22]]$evidence_items #> $content$records[[1]]$variants[[22]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[22]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[22]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[1]]$variants[[23]] #> $content$records[[1]]$variants[[23]]$name #> [1] "RANBP2-ALK" #> #> $content$records[[1]]$variants[[23]]$id #> [1] 514 #> #> $content$records[[1]]$variants[[23]]$evidence_items #> $content$records[[1]]$variants[[23]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[1]]$variants[[23]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[23]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[24]] #> $content$records[[1]]$variants[[24]]$name #> [1] "ALTERNATIVE TRANSCRIPT (ATI)" #> #> $content$records[[1]]$variants[[24]]$id #> [1] 839 #> #> $content$records[[1]]$variants[[24]]$evidence_items #> $content$records[[1]]$variants[[24]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[1]]$variants[[24]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[24]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[1]]$variants[[25]] #> $content$records[[1]]$variants[[25]]$name #> [1] "R1275Q" #> #> $content$records[[1]]$variants[[25]]$id #> [1] 9 #> #> $content$records[[1]]$variants[[25]]$evidence_items #> $content$records[[1]]$variants[[25]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[1]]$variants[[25]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[25]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[1]]$variants[[26]] #> $content$records[[1]]$variants[[26]]$name #> [1] "EML4-ALK E6;A20" #> #> $content$records[[1]]$variants[[26]]$id #> [1] 503 #> #> $content$records[[1]]$variants[[26]]$evidence_items #> $content$records[[1]]$variants[[26]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[1]]$variants[[26]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[26]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[27]] #> $content$records[[1]]$variants[[27]]$name #> [1] "EML4-ALK E2;A20" #> #> $content$records[[1]]$variants[[27]]$id #> [1] 501 #> #> $content$records[[1]]$variants[[27]]$evidence_items #> $content$records[[1]]$variants[[27]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[1]]$variants[[27]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[27]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[28]] #> $content$records[[1]]$variants[[28]]$name #> [1] "CLTC-ALK" #> #> $content$records[[1]]$variants[[28]]$id #> [1] 520 #> #> $content$records[[1]]$variants[[28]]$evidence_items #> $content$records[[1]]$variants[[28]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[1]]$variants[[28]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[28]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[29]] #> $content$records[[1]]$variants[[29]]$name #> [1] "EML4-ALK AMPLIFICATION" #> #> $content$records[[1]]$variants[[29]]$id #> [1] 170 #> #> $content$records[[1]]$variants[[29]]$evidence_items #> $content$records[[1]]$variants[[29]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[1]]$variants[[29]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[29]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[1]]$variants[[30]] #> $content$records[[1]]$variants[[30]]$name #> [1] "EML4-ALK S1206Y" #> #> $content$records[[1]]$variants[[30]]$id #> [1] 172 #> #> $content$records[[1]]$variants[[30]]$evidence_items #> $content$records[[1]]$variants[[30]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[1]]$variants[[30]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[30]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[1]]$variants[[31]] #> $content$records[[1]]$variants[[31]]$name #> [1] "EML4-ALK" #> #> $content$records[[1]]$variants[[31]]$id #> [1] 5 #> #> $content$records[[1]]$variants[[31]]$evidence_items #> $content$records[[1]]$variants[[31]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[1]]$variants[[31]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[31]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> #> $content$records[[1]]$aliases #> $content$records[[1]]$aliases[[1]] #> [1] "CD246" #> #> $content$records[[1]]$aliases[[2]] #> [1] "NBLST3" #> #> $content$records[[1]]$aliases[[3]] #> [1] "ALK" #> #> #> $content$records[[1]]$type #> [1] "gene" #> #> #> $content$records[[2]] #> $content$records[[2]]$id #> [1] 2 #> #> $content$records[[2]]$name #> [1] "AKT1" #> #> $content$records[[2]]$entrez_id #> [1] 207 #> #> $content$records[[2]]$description #> [1] "AKT1, also referred to as protein kinase B, is a known oncogene. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to result in activation of the protein. Mutations in AKT1 have also been shown to confer resistance to allosteric kinase inhibitors in vitro." #> #> $content$records[[2]]$variants #> $content$records[[2]]$variants[[1]] #> $content$records[[2]]$variants[[1]]$name #> [1] "E17K" #> #> $content$records[[2]]$variants[[1]]$id #> [1] 4 #> #> $content$records[[2]]$variants[[1]]$evidence_items #> $content$records[[2]]$variants[[1]]$evidence_items$accepted_count #> [1] 5 #> #> $content$records[[2]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[2]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[2]]$variants[[2]] #> $content$records[[2]]$variants[[2]]$name #> [1] "Q79K" #> #> $content$records[[2]]$variants[[2]]$id #> [1] 169 #> #> $content$records[[2]]$variants[[2]]$evidence_items #> $content$records[[2]]$variants[[2]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[2]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[2]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[2]]$variants[[3]] #> $content$records[[2]]$variants[[3]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[2]]$variants[[3]]$id #> [1] 2360 #> #> $content$records[[2]]$variants[[3]]$evidence_items #> $content$records[[2]]$variants[[3]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[2]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[2]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[2]]$aliases #> $content$records[[2]]$aliases[[1]] #> [1] "PRKBA" #> #> $content$records[[2]]$aliases[[2]] #> [1] "RAC" #> #> $content$records[[2]]$aliases[[3]] #> [1] "RAC-ALPHA" #> #> $content$records[[2]]$aliases[[4]] #> [1] "CWS6" #> #> $content$records[[2]]$aliases[[5]] #> [1] "PKB-ALPHA" #> #> $content$records[[2]]$aliases[[6]] #> [1] "PKB" #> #> $content$records[[2]]$aliases[[7]] #> [1] "AKT" #> #> $content$records[[2]]$aliases[[8]] #> [1] "AKT1" #> #> #> $content$records[[2]]$type #> [1] "gene" #> #> #> $content$records[[3]] #> $content$records[[3]]$id #> [1] 3 #> #> $content$records[[3]]$name #> [1] "ARAF" #> #> $content$records[[3]]$entrez_id #> [1] 369 #> #> $content$records[[3]]$description #> [1] "ARAF has recently become increasingly considered for its oncogenic potential. Its potential as a target for informing clinical action was demonstrated by a single case of advanced lung adenocarcinoma harboring an S214C mutation that, when treated with sorafenib, acheived near-complete clinical remission. This finding has brought new focus on ARAF as a marker that should be assayed for in cancer treatment." #> #> $content$records[[3]]$variants #> $content$records[[3]]$variants[[1]] #> $content$records[[3]]$variants[[1]]$name #> [1] "S214C" #> #> $content$records[[3]]$variants[[1]]$id #> [1] 10 #> #> $content$records[[3]]$variants[[1]]$evidence_items #> $content$records[[3]]$variants[[1]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[3]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[3]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[3]]$variants[[2]] #> $content$records[[3]]$variants[[2]]$name #> [1] "S490T" #> #> $content$records[[3]]$variants[[2]]$id #> [1] 825 #> #> $content$records[[3]]$variants[[2]]$evidence_items #> $content$records[[3]]$variants[[2]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[3]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[3]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[3]]$aliases #> $content$records[[3]]$aliases[[1]] #> [1] "ARAF1" #> #> $content$records[[3]]$aliases[[2]] #> [1] "PKS2" #> #> $content$records[[3]]$aliases[[3]] #> [1] "A-RAF" #> #> $content$records[[3]]$aliases[[4]] #> [1] "RAFA1" #> #> $content$records[[3]]$aliases[[5]] #> [1] "ARAF" #> #> #> $content$records[[3]]$type #> [1] "gene" #> #> #> $content$records[[4]] #> $content$records[[4]]$id #> [1] 4 #> #> $content$records[[4]]$name #> [1] "ABL1" #> #> $content$records[[4]]$entrez_id #> [1] 25 #> #> $content$records[[4]]$description #> [1] "ABL1 is most relevant to cancer in its role in the BCR-ABL fusion protein that has become a signature of chronic myeloid leukemia (CML). Cells harboring this fusion have shown sensitivity to imatinib, greatly improving the prognostic outlook of the disease. However, additional mutations in ABL1 have been shown to confer resistance to imatinib. In these resistance cases, second-generation tyrosine kinase inhibitors such as dasatinib and nilotinib have exhibited some efficacy and are currently undergoing clinical trials for treating acquired resistance in CML." #> #> $content$records[[4]]$variants #> $content$records[[4]]$variants[[1]] #> $content$records[[4]]$variants[[1]]$name #> [1] "BCR-ABL E355G" #> #> $content$records[[4]]$variants[[1]]$id #> [1] 1487 #> #> $content$records[[4]]$variants[[1]]$evidence_items #> $content$records[[4]]$variants[[1]]$evidence_items$accepted_count #> [1] 5 #> #> $content$records[[4]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[1]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[4]]$variants[[2]] #> $content$records[[4]]$variants[[2]]$name #> [1] "BCR-ABL F317L" #> #> $content$records[[4]]$variants[[2]]$id #> [1] 241 #> #> $content$records[[4]]$variants[[2]]$evidence_items #> $content$records[[4]]$variants[[2]]$evidence_items$accepted_count #> [1] 15 #> #> $content$records[[4]]$variants[[2]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[4]]$variants[[2]]$evidence_items$submitted_count #> [1] 14 #> #> #> #> $content$records[[4]]$variants[[3]] #> $content$records[[4]]$variants[[3]]$name #> [1] "BCR-ABL M244V" #> #> $content$records[[4]]$variants[[3]]$id #> [1] 1021 #> #> $content$records[[4]]$variants[[3]]$evidence_items #> $content$records[[4]]$variants[[3]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[4]]$variants[[3]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[4]]$variants[[3]]$evidence_items$submitted_count #> [1] 7 #> #> #> #> $content$records[[4]]$variants[[4]] #> $content$records[[4]]$variants[[4]]$name #> [1] "BCR-ABL L387M" #> #> $content$records[[4]]$variants[[4]]$id #> [1] 1488 #> #> $content$records[[4]]$variants[[4]]$evidence_items #> $content$records[[4]]$variants[[4]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[4]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[5]] #> $content$records[[4]]$variants[[5]]$name #> [1] "Y253F" #> #> $content$records[[4]]$variants[[5]]$id #> [1] 1026 #> #> $content$records[[4]]$variants[[5]]$evidence_items #> $content$records[[4]]$variants[[5]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[4]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[5]]$evidence_items$submitted_count #> [1] 10 #> #> #> #> $content$records[[4]]$variants[[6]] #> $content$records[[4]]$variants[[6]]$name #> [1] "BCR-ABL F311L" #> #> $content$records[[4]]$variants[[6]]$id #> [1] 1528 #> #> $content$records[[4]]$variants[[6]]$evidence_items #> $content$records[[4]]$variants[[6]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[6]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[7]] #> $content$records[[4]]$variants[[7]]$name #> [1] "BCR-ABL M351T" #> #> $content$records[[4]]$variants[[7]]$id #> [1] 1029 #> #> $content$records[[4]]$variants[[7]]$evidence_items #> $content$records[[4]]$variants[[7]]$evidence_items$accepted_count #> [1] 9 #> #> $content$records[[4]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[7]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[4]]$variants[[8]] #> $content$records[[4]]$variants[[8]]$name #> [1] "BCR-ABL L248V" #> #> $content$records[[4]]$variants[[8]]$id #> [1] 1022 #> #> $content$records[[4]]$variants[[8]]$evidence_items #> $content$records[[4]]$variants[[8]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[4]]$variants[[8]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[4]]$variants[[8]]$evidence_items$submitted_count #> [1] 6 #> #> #> #> $content$records[[4]]$variants[[9]] #> $content$records[[4]]$variants[[9]]$name #> [1] "BCR-ABL F359V" #> #> $content$records[[4]]$variants[[9]]$id #> [1] 892 #> #> $content$records[[4]]$variants[[9]]$evidence_items #> $content$records[[4]]$variants[[9]]$evidence_items$accepted_count #> [1] 11 #> #> $content$records[[4]]$variants[[9]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[4]]$variants[[9]]$evidence_items$submitted_count #> [1] 6 #> #> #> #> $content$records[[4]]$variants[[10]] #> $content$records[[4]]$variants[[10]]$name #> [1] "BCR-ABL G398R" #> #> $content$records[[4]]$variants[[10]]$id #> [1] 1233 #> #> $content$records[[4]]$variants[[10]]$evidence_items #> $content$records[[4]]$variants[[10]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[10]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[11]] #> $content$records[[4]]$variants[[11]]$name #> [1] "BCR-ABL E453K" #> #> $content$records[[4]]$variants[[11]]$id #> [1] 1535 #> #> $content$records[[4]]$variants[[11]]$evidence_items #> $content$records[[4]]$variants[[11]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[11]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[12]] #> $content$records[[4]]$variants[[12]]$name #> [1] "BCR-ABL D276G" #> #> $content$records[[4]]$variants[[12]]$id #> [1] 1027 #> #> $content$records[[4]]$variants[[12]]$evidence_items #> $content$records[[4]]$variants[[12]]$evidence_items$accepted_count #> [1] 5 #> #> $content$records[[4]]$variants[[12]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[4]]$variants[[12]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[4]]$variants[[13]] #> $content$records[[4]]$variants[[13]]$name #> [1] "BCR-ABL H396R" #> #> $content$records[[4]]$variants[[13]]$id #> [1] 1030 #> #> $content$records[[4]]$variants[[13]]$evidence_items #> $content$records[[4]]$variants[[13]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[4]]$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[13]]$evidence_items$submitted_count #> [1] 7 #> #> #> #> $content$records[[4]]$variants[[14]] #> $content$records[[4]]$variants[[14]]$name #> [1] "BCR-ABL E255V" #> #> $content$records[[4]]$variants[[14]]$id #> [1] 1173 #> #> $content$records[[4]]$variants[[14]]$evidence_items #> $content$records[[4]]$variants[[14]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[4]]$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[14]]$evidence_items$submitted_count #> [1] 10 #> #> #> #> $content$records[[4]]$variants[[15]] #> $content$records[[4]]$variants[[15]]$name #> [1] "BCR-ABL E450V" #> #> $content$records[[4]]$variants[[15]]$id #> [1] 1534 #> #> $content$records[[4]]$variants[[15]]$evidence_items #> $content$records[[4]]$variants[[15]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[15]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[16]] #> $content$records[[4]]$variants[[16]]$name #> [1] "FOXP1-ABL1" #> #> $content$records[[4]]$variants[[16]]$id #> [1] 2698 #> #> $content$records[[4]]$variants[[16]]$evidence_items #> $content$records[[4]]$variants[[16]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[16]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[17]] #> $content$records[[4]]$variants[[17]]$name #> [1] "BCR-ABL E453Q" #> #> $content$records[[4]]$variants[[17]]$id #> [1] 1509 #> #> $content$records[[4]]$variants[[17]]$evidence_items #> $content$records[[4]]$variants[[17]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[17]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[18]] #> $content$records[[4]]$variants[[18]]$name #> [1] "P-Loop Mutation" #> #> $content$records[[4]]$variants[[18]]$id #> [1] 2375 #> #> $content$records[[4]]$variants[[18]]$evidence_items #> $content$records[[4]]$variants[[18]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[18]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[19]] #> $content$records[[4]]$variants[[19]]$name #> [1] "BCR-ABL N331S" #> #> $content$records[[4]]$variants[[19]]$id #> [1] 1529 #> #> $content$records[[4]]$variants[[19]]$evidence_items #> $content$records[[4]]$variants[[19]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[19]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[19]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[20]] #> $content$records[[4]]$variants[[20]]$name #> [1] "BCR-ABL A397P" #> #> $content$records[[4]]$variants[[20]]$id #> [1] 1612 #> #> $content$records[[4]]$variants[[20]]$evidence_items #> $content$records[[4]]$variants[[20]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[20]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[20]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[21]] #> $content$records[[4]]$variants[[21]]$name #> [1] "BCR-ABL L248R" #> #> $content$records[[4]]$variants[[21]]$id #> [1] 2340 #> #> $content$records[[4]]$variants[[21]]$evidence_items #> $content$records[[4]]$variants[[21]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[21]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[21]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[22]] #> $content$records[[4]]$variants[[22]]$name #> [1] "E279K" #> #> $content$records[[4]]$variants[[22]]$id #> [1] 1526 #> #> $content$records[[4]]$variants[[22]]$evidence_items #> $content$records[[4]]$variants[[22]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[22]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[22]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[23]] #> $content$records[[4]]$variants[[23]]$name #> [1] "BCR-ABL" #> #> $content$records[[4]]$variants[[23]]$id #> [1] 1 #> #> $content$records[[4]]$variants[[23]]$evidence_items #> $content$records[[4]]$variants[[23]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[4]]$variants[[23]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[23]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[24]] #> $content$records[[4]]$variants[[24]]$name #> [1] "D421G" #> #> $content$records[[4]]$variants[[24]]$id #> [1] 1532 #> #> $content$records[[4]]$variants[[24]]$evidence_items #> $content$records[[4]]$variants[[24]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[24]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[24]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[25]] #> $content$records[[4]]$variants[[25]]$name #> [1] "BCR-ABL V299L" #> #> $content$records[[4]]$variants[[25]]$id #> [1] 1231 #> #> $content$records[[4]]$variants[[25]]$evidence_items #> $content$records[[4]]$variants[[25]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[4]]$variants[[25]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[25]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[4]]$variants[[26]] #> $content$records[[4]]$variants[[26]]$name #> [1] "N336S" #> #> $content$records[[4]]$variants[[26]]$id #> [1] 1640 #> #> $content$records[[4]]$variants[[26]]$evidence_items #> $content$records[[4]]$variants[[26]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[26]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[26]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[27]] #> $content$records[[4]]$variants[[27]]$name #> [1] "Non-P-Loop Mutation" #> #> $content$records[[4]]$variants[[27]]$id #> [1] 2376 #> #> $content$records[[4]]$variants[[27]]$evidence_items #> $content$records[[4]]$variants[[27]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[27]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[27]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[28]] #> $content$records[[4]]$variants[[28]]$name #> [1] "Q300R" #> #> $content$records[[4]]$variants[[28]]$id #> [1] 1527 #> #> $content$records[[4]]$variants[[28]]$evidence_items #> $content$records[[4]]$variants[[28]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[28]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[28]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[29]] #> $content$records[[4]]$variants[[29]]$name #> [1] "BCR-ABL L364P" #> #> $content$records[[4]]$variants[[29]]$id #> [1] 1530 #> #> $content$records[[4]]$variants[[29]]$evidence_items #> $content$records[[4]]$variants[[29]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[29]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[29]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[30]] #> $content$records[[4]]$variants[[30]]$name #> [1] "BCR-ABL F317S" #> #> $content$records[[4]]$variants[[30]]$id #> [1] 2343 #> #> $content$records[[4]]$variants[[30]]$evidence_items #> $content$records[[4]]$variants[[30]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[30]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[30]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[31]] #> $content$records[[4]]$variants[[31]]$name #> [1] "BCR-ABL P480A" #> #> $content$records[[4]]$variants[[31]]$id #> [1] 1537 #> #> $content$records[[4]]$variants[[31]]$evidence_items #> $content$records[[4]]$variants[[31]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[31]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[31]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[32]] #> $content$records[[4]]$variants[[32]]$name #> [1] "C475V" #> #> $content$records[[4]]$variants[[32]]$id #> [1] 1639 #> #> $content$records[[4]]$variants[[32]]$evidence_items #> $content$records[[4]]$variants[[32]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[32]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[32]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[33]] #> $content$records[[4]]$variants[[33]]$name #> [1] "BCR-ABL F317V" #> #> $content$records[[4]]$variants[[33]]$id #> [1] 1525 #> #> $content$records[[4]]$variants[[33]]$evidence_items #> $content$records[[4]]$variants[[33]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[33]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[33]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[34]] #> $content$records[[4]]$variants[[34]]$name #> [1] "TKD MUTATION" #> #> $content$records[[4]]$variants[[34]]$id #> [1] 2371 #> #> $content$records[[4]]$variants[[34]]$evidence_items #> $content$records[[4]]$variants[[34]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[4]]$variants[[34]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[34]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[35]] #> $content$records[[4]]$variants[[35]]$name #> [1] "BCR-ABL T315A" #> #> $content$records[[4]]$variants[[35]]$id #> [1] 2335 #> #> $content$records[[4]]$variants[[35]]$evidence_items #> $content$records[[4]]$variants[[35]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[35]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[35]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[36]] #> $content$records[[4]]$variants[[36]]$name #> [1] "BCR-ABL E459K" #> #> $content$records[[4]]$variants[[36]]$id #> [1] 2370 #> #> $content$records[[4]]$variants[[36]]$evidence_items #> $content$records[[4]]$variants[[36]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[4]]$variants[[36]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[36]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[37]] #> $content$records[[4]]$variants[[37]]$name #> [1] "BCR-ABL V379I" #> #> $content$records[[4]]$variants[[37]]$id #> [1] 1609 #> #> $content$records[[4]]$variants[[37]]$evidence_items #> $content$records[[4]]$variants[[37]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[4]]$variants[[37]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[37]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[4]]$variants[[38]] #> $content$records[[4]]$variants[[38]]$name #> [1] "R351W" #> #> $content$records[[4]]$variants[[38]]$id #> [1] 1656 #> #> $content$records[[4]]$variants[[38]]$evidence_items #> $content$records[[4]]$variants[[38]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[38]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[38]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[39]] #> $content$records[[4]]$variants[[39]]$name #> [1] "BCR-ABL T315I" #> #> $content$records[[4]]$variants[[39]]$id #> [1] 2 #> #> $content$records[[4]]$variants[[39]]$evidence_items #> $content$records[[4]]$variants[[39]]$evidence_items$accepted_count #> [1] 17 #> #> $content$records[[4]]$variants[[39]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[39]]$evidence_items$submitted_count #> [1] 22 #> #> #> #> $content$records[[4]]$variants[[40]] #> $content$records[[4]]$variants[[40]]$name #> [1] "BCR-ABL H396P" #> #> $content$records[[4]]$variants[[40]]$id #> [1] 1531 #> #> $content$records[[4]]$variants[[40]]$evidence_items #> $content$records[[4]]$variants[[40]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[40]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[40]]$evidence_items$submitted_count #> [1] 5 #> #> #> #> $content$records[[4]]$variants[[41]] #> $content$records[[4]]$variants[[41]]$name #> [1] "BCR-ABL G250E" #> #> $content$records[[4]]$variants[[41]]$id #> [1] 1023 #> #> $content$records[[4]]$variants[[41]]$evidence_items #> $content$records[[4]]$variants[[41]]$evidence_items$accepted_count #> [1] 11 #> #> $content$records[[4]]$variants[[41]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[41]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[4]]$variants[[42]] #> $content$records[[4]]$variants[[42]]$name #> [1] "BCR-ABL L387F" #> #> $content$records[[4]]$variants[[42]]$id #> [1] 1232 #> #> $content$records[[4]]$variants[[42]]$evidence_items #> $content$records[[4]]$variants[[42]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[4]]$variants[[42]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[42]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[43]] #> $content$records[[4]]$variants[[43]]$name #> [1] "BCR-ABL F317C" #> #> $content$records[[4]]$variants[[43]]$id #> [1] 2359 #> #> $content$records[[4]]$variants[[43]]$evidence_items #> $content$records[[4]]$variants[[43]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[43]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[43]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[44]] #> $content$records[[4]]$variants[[44]]$name #> [1] "BCR-ABL F486S" #> #> $content$records[[4]]$variants[[44]]$id #> [1] 1152 #> #> $content$records[[4]]$variants[[44]]$evidence_items #> $content$records[[4]]$variants[[44]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[4]]$variants[[44]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[44]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[45]] #> $content$records[[4]]$variants[[45]]$name #> [1] "BCR-ABL F359C" #> #> $content$records[[4]]$variants[[45]]$id #> [1] 1184 #> #> $content$records[[4]]$variants[[45]]$evidence_items #> $content$records[[4]]$variants[[45]]$evidence_items$accepted_count #> [1] 8 #> #> $content$records[[4]]$variants[[45]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[45]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[4]]$variants[[46]] #> $content$records[[4]]$variants[[46]]$name #> [1] "L298V" #> #> $content$records[[4]]$variants[[46]]$id #> [1] 1506 #> #> $content$records[[4]]$variants[[46]]$evidence_items #> $content$records[[4]]$variants[[46]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[46]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[46]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[47]] #> $content$records[[4]]$variants[[47]]$name #> [1] "BCR-ABL E453A" #> #> $content$records[[4]]$variants[[47]]$id #> [1] 1536 #> #> $content$records[[4]]$variants[[47]]$evidence_items #> $content$records[[4]]$variants[[47]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[47]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[47]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[48]] #> $content$records[[4]]$variants[[48]]$name #> [1] "E292V" #> #> $content$records[[4]]$variants[[48]]$id #> [1] 1183 #> #> $content$records[[4]]$variants[[48]]$evidence_items #> $content$records[[4]]$variants[[48]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[48]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[48]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[49]] #> $content$records[[4]]$variants[[49]]$name #> [1] "G340L" #> #> $content$records[[4]]$variants[[49]]$id #> [1] 1657 #> #> $content$records[[4]]$variants[[49]]$evidence_items #> $content$records[[4]]$variants[[49]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[49]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[49]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[50]] #> $content$records[[4]]$variants[[50]]$name #> [1] "L384M" #> #> $content$records[[4]]$variants[[50]]$id #> [1] 1230 #> #> $content$records[[4]]$variants[[50]]$evidence_items #> $content$records[[4]]$variants[[50]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[50]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[50]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[4]]$variants[[51]] #> $content$records[[4]]$variants[[51]]$name #> [1] "BCR-ABL F317I" #> #> $content$records[[4]]$variants[[51]]$id #> [1] 1625 #> #> $content$records[[4]]$variants[[51]]$evidence_items #> $content$records[[4]]$variants[[51]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[51]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[51]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[52]] #> $content$records[[4]]$variants[[52]]$name #> [1] "BCR-ABL Y253H" #> #> $content$records[[4]]$variants[[52]]$id #> [1] 1025 #> #> $content$records[[4]]$variants[[52]]$evidence_items #> $content$records[[4]]$variants[[52]]$evidence_items$accepted_count #> [1] 8 #> #> $content$records[[4]]$variants[[52]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[52]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[4]]$variants[[53]] #> $content$records[[4]]$variants[[53]]$name #> [1] "BCR-ABL F311I" #> #> $content$records[[4]]$variants[[53]]$id #> [1] 1507 #> #> $content$records[[4]]$variants[[53]]$evidence_items #> $content$records[[4]]$variants[[53]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[53]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[4]]$variants[[53]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[54]] #> $content$records[[4]]$variants[[54]]$name #> [1] "BCR-ABL F359I" #> #> $content$records[[4]]$variants[[54]]$id #> [1] 1523 #> #> $content$records[[4]]$variants[[54]]$evidence_items #> $content$records[[4]]$variants[[54]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[4]]$variants[[54]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[54]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[55]] #> $content$records[[4]]$variants[[55]]$name #> [1] "Q252H" #> #> $content$records[[4]]$variants[[55]]$id #> [1] 1024 #> #> $content$records[[4]]$variants[[55]]$evidence_items #> $content$records[[4]]$variants[[55]]$evidence_items$accepted_count #> [1] 5 #> #> $content$records[[4]]$variants[[55]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[55]]$evidence_items$submitted_count #> [1] 11 #> #> #> #> $content$records[[4]]$variants[[56]] #> $content$records[[4]]$variants[[56]]$name #> [1] "BCR-ABL E255K" #> #> $content$records[[4]]$variants[[56]]$id #> [1] 3 #> #> $content$records[[4]]$variants[[56]]$evidence_items #> $content$records[[4]]$variants[[56]]$evidence_items$accepted_count #> [1] 15 #> #> $content$records[[4]]$variants[[56]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[56]]$evidence_items$submitted_count #> [1] 9 #> #> #> #> #> $content$records[[4]]$aliases #> $content$records[[4]]$aliases[[1]] #> [1] "ABL1" #> #> $content$records[[4]]$aliases[[2]] #> [1] "v-abl" #> #> $content$records[[4]]$aliases[[3]] #> [1] "p150" #> #> $content$records[[4]]$aliases[[4]] #> [1] "c-ABL1" #> #> $content$records[[4]]$aliases[[5]] #> [1] "c-ABL" #> #> $content$records[[4]]$aliases[[6]] #> [1] "bcr/abl" #> #> $content$records[[4]]$aliases[[7]] #> [1] "JTK7" #> #> $content$records[[4]]$aliases[[8]] #> [1] "ABL" #> #> #> $content$records[[4]]$type #> [1] "gene" #> #> #> $content$records[[5]] #> $content$records[[5]]$id #> [1] 5 #> #> $content$records[[5]]$name #> [1] "BRAF" #> #> $content$records[[5]]$entrez_id #> [1] 673 #> #> $content$records[[5]]$description #> [1] "BRAF mutations are found to be recurrent in many cancer types. Of these, the mutation of valine 600 to glutamic acid (V600E) is the most prevalent. V600E has been determined to be an activating mutation, and cells that harbor it, along with other V600 mutations are sensitive to the BRAF inhibitor dabrafenib. It is also common to use MEK inhibition as a substitute for BRAF inhibitors, and the MEK inhibitor trametinib has seen some success in BRAF mutant melanomas. BRAF mutations have also been correlated with poor prognosis in many cancer types, although there is at least one study that questions this conclusion in papillary thyroid cancer." #> #> $content$records[[5]]$variants #> $content$records[[5]]$variants[[1]] #> $content$records[[5]]$variants[[1]]$name #> [1] "G596R" #> #> $content$records[[5]]$variants[[1]]$id #> [1] 1627 #> #> $content$records[[5]]$variants[[1]]$evidence_items #> $content$records[[5]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[1]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[5]]$variants[[2]] #> $content$records[[5]]$variants[[2]]$name #> [1] "V600" #> #> $content$records[[5]]$variants[[2]]$id #> [1] 17 #> #> $content$records[[5]]$variants[[2]]$evidence_items #> $content$records[[5]]$variants[[2]]$evidence_items$accepted_count #> [1] 22 #> #> $content$records[[5]]$variants[[2]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[5]]$variants[[2]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[5]]$variants[[3]] #> $content$records[[5]]$variants[[3]]$name #> [1] "L597S" #> #> $content$records[[5]]$variants[[3]]$id #> [1] 582 #> #> $content$records[[5]]$variants[[3]]$evidence_items #> $content$records[[5]]$variants[[3]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[4]] #> $content$records[[5]]$variants[[4]]$name #> [1] "AGK-BRAF" #> #> $content$records[[5]]$variants[[4]]$id #> [1] 285 #> #> $content$records[[5]]$variants[[4]]$evidence_items #> $content$records[[5]]$variants[[4]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[4]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[5]] #> $content$records[[5]]$variants[[5]]$name #> [1] "D594V" #> #> $content$records[[5]]$variants[[5]]$id #> [1] 580 #> #> $content$records[[5]]$variants[[5]]$evidence_items #> $content$records[[5]]$variants[[5]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[5]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[6]] #> $content$records[[5]]$variants[[6]]$name #> [1] "Non-V600" #> #> $content$records[[5]]$variants[[6]]$id #> [1] 2408 #> #> $content$records[[5]]$variants[[6]]$evidence_items #> $content$records[[5]]$variants[[6]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[6]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[7]] #> $content$records[[5]]$variants[[7]]$name #> [1] "G606E" #> #> $content$records[[5]]$variants[[7]]$id #> [1] 2223 #> #> $content$records[[5]]$variants[[7]]$evidence_items #> $content$records[[5]]$variants[[7]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[7]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[8]] #> $content$records[[5]]$variants[[8]]$name #> [1] "intron 9 rearrangement" #> #> $content$records[[5]]$variants[[8]]$id #> [1] 2225 #> #> $content$records[[5]]$variants[[8]]$evidence_items #> $content$records[[5]]$variants[[8]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[8]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[8]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[9]] #> $content$records[[5]]$variants[[9]]$name #> [1] "AKAP9-BRAF" #> #> $content$records[[5]]$variants[[9]]$id #> [1] 184 #> #> $content$records[[5]]$variants[[9]]$evidence_items #> $content$records[[5]]$variants[[9]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[9]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[10]] #> $content$records[[5]]$variants[[10]]$name #> [1] "G464V" #> #> $content$records[[5]]$variants[[10]]$id #> [1] 1106 #> #> $content$records[[5]]$variants[[10]]$evidence_items #> $content$records[[5]]$variants[[10]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[10]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[5]]$variants[[11]] #> $content$records[[5]]$variants[[11]]$name #> [1] "K483M" #> #> $content$records[[5]]$variants[[11]]$id #> [1] 581 #> #> $content$records[[5]]$variants[[11]]$evidence_items #> $content$records[[5]]$variants[[11]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[11]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[12]] #> $content$records[[5]]$variants[[12]]$name #> [1] "BRAF-CUL1" #> #> $content$records[[5]]$variants[[12]]$id #> [1] 656 #> #> $content$records[[5]]$variants[[12]]$evidence_items #> $content$records[[5]]$variants[[12]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[12]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[12]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[13]] #> $content$records[[5]]$variants[[13]]$name #> [1] "G496A" #> #> $content$records[[5]]$variants[[13]]$id #> [1] 2221 #> #> $content$records[[5]]$variants[[13]]$evidence_items #> $content$records[[5]]$variants[[13]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[13]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[14]] #> $content$records[[5]]$variants[[14]]$name #> [1] "CUX1-BRAF" #> #> $content$records[[5]]$variants[[14]]$id #> [1] 2229 #> #> $content$records[[5]]$variants[[14]]$evidence_items #> $content$records[[5]]$variants[[14]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[14]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[15]] #> $content$records[[5]]$variants[[15]]$name #> [1] "V600D" #> #> $content$records[[5]]$variants[[15]]$id #> [1] 11 #> #> $content$records[[5]]$variants[[15]]$evidence_items #> $content$records[[5]]$variants[[15]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[5]]$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[15]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[16]] #> $content$records[[5]]$variants[[16]]$name #> [1] "V600K" #> #> $content$records[[5]]$variants[[16]]$id #> [1] 563 #> #> $content$records[[5]]$variants[[16]]$evidence_items #> $content$records[[5]]$variants[[16]]$evidence_items$accepted_count #> [1] 8 #> #> $content$records[[5]]$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[16]]$evidence_items$submitted_count #> [1] 10 #> #> #> #> $content$records[[5]]$variants[[17]] #> $content$records[[5]]$variants[[17]]$name #> [1] "D594G" #> #> $content$records[[5]]$variants[[17]]$id #> [1] 611 #> #> $content$records[[5]]$variants[[17]]$evidence_items #> $content$records[[5]]$variants[[17]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[5]]$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[17]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[18]] #> $content$records[[5]]$variants[[18]]$name #> [1] "N581S" #> #> $content$records[[5]]$variants[[18]]$id #> [1] 1186 #> #> $content$records[[5]]$variants[[18]]$evidence_items #> $content$records[[5]]$variants[[18]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[18]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[19]] #> $content$records[[5]]$variants[[19]]$name #> [1] "L597R" #> #> $content$records[[5]]$variants[[19]]$id #> [1] 288 #> #> $content$records[[5]]$variants[[19]]$evidence_items #> $content$records[[5]]$variants[[19]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[19]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[19]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[20]] #> $content$records[[5]]$variants[[20]]$name #> [1] "V600E" #> #> $content$records[[5]]$variants[[20]]$id #> [1] 12 #> #> $content$records[[5]]$variants[[20]]$evidence_items #> $content$records[[5]]$variants[[20]]$evidence_items$accepted_count #> [1] 81 #> #> $content$records[[5]]$variants[[20]]$evidence_items$rejected_count #> [1] 7 #> #> $content$records[[5]]$variants[[20]]$evidence_items$submitted_count #> [1] 75 #> #> #> #> $content$records[[5]]$variants[[21]] #> $content$records[[5]]$variants[[21]]$name #> [1] "D594K" #> #> $content$records[[5]]$variants[[21]]$id #> [1] 2398 #> #> $content$records[[5]]$variants[[21]]$evidence_items #> $content$records[[5]]$variants[[21]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[21]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[21]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[22]] #> $content$records[[5]]$variants[[22]]$name #> [1] "G469A" #> #> $content$records[[5]]$variants[[22]]$id #> [1] 992 #> #> $content$records[[5]]$variants[[22]]$evidence_items #> $content$records[[5]]$variants[[22]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[22]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[22]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[5]]$variants[[23]] #> $content$records[[5]]$variants[[23]]$name #> [1] "V600E/K AMPLIFICATION" #> #> $content$records[[5]]$variants[[23]]$id #> [1] 2361 #> #> $content$records[[5]]$variants[[23]]$evidence_items #> $content$records[[5]]$variants[[23]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[23]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[23]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[24]] #> $content$records[[5]]$variants[[24]]$name #> [1] "P731T" #> #> $content$records[[5]]$variants[[24]]$id #> [1] 2224 #> #> $content$records[[5]]$variants[[24]]$evidence_items #> $content$records[[5]]$variants[[24]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[24]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[24]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[25]] #> $content$records[[5]]$variants[[25]]$name #> [1] "V600E AMPLIFICATION" #> #> $content$records[[5]]$variants[[25]]$id #> [1] 14 #> #> $content$records[[5]]$variants[[25]]$evidence_items #> $content$records[[5]]$variants[[25]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[25]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[25]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[26]] #> $content$records[[5]]$variants[[26]]$name #> [1] "L597V" #> #> $content$records[[5]]$variants[[26]]$id #> [1] 585 #> #> $content$records[[5]]$variants[[26]]$evidence_items #> $content$records[[5]]$variants[[26]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[26]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[26]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[27]] #> $content$records[[5]]$variants[[27]]$name #> [1] "AMPLIFICATION" #> #> $content$records[[5]]$variants[[27]]$id #> [1] 1269 #> #> $content$records[[5]]$variants[[27]]$evidence_items #> $content$records[[5]]$variants[[27]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[27]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[27]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[28]] #> $content$records[[5]]$variants[[28]]$name #> [1] "K601E" #> #> $content$records[[5]]$variants[[28]]$id #> [1] 584 #> #> $content$records[[5]]$variants[[28]]$evidence_items #> $content$records[[5]]$variants[[28]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[28]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[28]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[5]]$variants[[29]] #> $content$records[[5]]$variants[[29]]$name #> [1] "DEL 485-490" #> #> $content$records[[5]]$variants[[29]]$id #> [1] 522 #> #> $content$records[[5]]$variants[[29]]$evidence_items #> $content$records[[5]]$variants[[29]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[29]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[29]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[30]] #> $content$records[[5]]$variants[[30]]$name #> [1] "L597Q" #> #> $content$records[[5]]$variants[[30]]$id #> [1] 583 #> #> $content$records[[5]]$variants[[30]]$evidence_items #> $content$records[[5]]$variants[[30]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[5]]$variants[[30]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[30]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[31]] #> $content$records[[5]]$variants[[31]]$name #> [1] "intron 10 rearrangement" #> #> $content$records[[5]]$variants[[31]]$id #> [1] 2226 #> #> $content$records[[5]]$variants[[31]]$evidence_items #> $content$records[[5]]$variants[[31]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[31]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[31]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[32]] #> $content$records[[5]]$variants[[32]]$name #> [1] "L505H" #> #> $content$records[[5]]$variants[[32]]$id #> [1] 658 #> #> $content$records[[5]]$variants[[32]]$evidence_items #> $content$records[[5]]$variants[[32]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[32]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[32]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[33]] #> $content$records[[5]]$variants[[33]]$name #> [1] "WASFL-BRAF Fusion" #> #> $content$records[[5]]$variants[[33]]$id #> [1] 2228 #> #> $content$records[[5]]$variants[[33]]$evidence_items #> $content$records[[5]]$variants[[33]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[33]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[33]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[34]] #> $content$records[[5]]$variants[[34]]$name #> [1] "WILD TYPE" #> #> $content$records[[5]]$variants[[34]]$id #> [1] 426 #> #> $content$records[[5]]$variants[[34]]$evidence_items #> $content$records[[5]]$variants[[34]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[34]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[34]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[35]] #> $content$records[[5]]$variants[[35]]$name #> [1] "MACF1-BRAF Fusion" #> #> $content$records[[5]]$variants[[35]]$id #> [1] 2227 #> #> $content$records[[5]]$variants[[35]]$evidence_items #> $content$records[[5]]$variants[[35]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[35]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[35]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[36]] #> $content$records[[5]]$variants[[36]]$name #> [1] "G596C" #> #> $content$records[[5]]$variants[[36]]$id #> [1] 694 #> #> $content$records[[5]]$variants[[36]]$evidence_items #> $content$records[[5]]$variants[[36]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[36]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[36]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[37]] #> $content$records[[5]]$variants[[37]]$name #> [1] "G469E" #> #> $content$records[[5]]$variants[[37]]$id #> [1] 993 #> #> $content$records[[5]]$variants[[37]]$evidence_items #> $content$records[[5]]$variants[[37]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[37]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[37]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[38]] #> $content$records[[5]]$variants[[38]]$name #> [1] "G466V" #> #> $content$records[[5]]$variants[[38]]$id #> [1] 2222 #> #> $content$records[[5]]$variants[[38]]$evidence_items #> $content$records[[5]]$variants[[38]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[38]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[38]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[39]] #> $content$records[[5]]$variants[[39]]$name #> [1] "PAPSS1-BRAF" #> #> $content$records[[5]]$variants[[39]]$id #> [1] 286 #> #> $content$records[[5]]$variants[[39]]$evidence_items #> $content$records[[5]]$variants[[39]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[39]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[39]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[40]] #> $content$records[[5]]$variants[[40]]$name #> [1] "KIAA1549-BRAF" #> #> $content$records[[5]]$variants[[40]]$id #> [1] 618 #> #> $content$records[[5]]$variants[[40]]$evidence_items #> $content$records[[5]]$variants[[40]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[5]]$variants[[40]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[5]]$variants[[40]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[5]]$variants[[41]] #> $content$records[[5]]$variants[[41]]$name #> [1] "PPFIBP2-BRAF" #> #> $content$records[[5]]$variants[[41]]$id #> [1] 617 #> #> $content$records[[5]]$variants[[41]]$evidence_items #> $content$records[[5]]$variants[[41]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[41]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[41]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[42]] #> $content$records[[5]]$variants[[42]]$name #> [1] "EXON 15 MUTATION" #> #> $content$records[[5]]$variants[[42]]$id #> [1] 2650 #> #> $content$records[[5]]$variants[[42]]$evidence_items #> $content$records[[5]]$variants[[42]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[42]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[42]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[43]] #> $content$records[[5]]$variants[[43]]$name #> [1] "V600E+V600M" #> #> $content$records[[5]]$variants[[43]]$id #> [1] 13 #> #> $content$records[[5]]$variants[[43]]$evidence_items #> $content$records[[5]]$variants[[43]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[43]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[43]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[44]] #> $content$records[[5]]$variants[[44]]$name #> [1] "D594A" #> #> $content$records[[5]]$variants[[44]]$id #> [1] 579 #> #> $content$records[[5]]$variants[[44]]$evidence_items #> $content$records[[5]]$variants[[44]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[44]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[44]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[45]] #> $content$records[[5]]$variants[[45]]$name #> [1] "ZKSCAN1-BRAF" #> #> $content$records[[5]]$variants[[45]]$id #> [1] 657 #> #> $content$records[[5]]$variants[[45]]$evidence_items #> $content$records[[5]]$variants[[45]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[45]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[45]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[46]] #> $content$records[[5]]$variants[[46]]$name #> [1] "TRIM24-BRAF" #> #> $content$records[[5]]$variants[[46]]$id #> [1] 287 #> #> $content$records[[5]]$variants[[46]]$evidence_items #> $content$records[[5]]$variants[[46]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[46]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[46]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[47]] #> $content$records[[5]]$variants[[47]]$name #> [1] "MUTATION" #> #> $content$records[[5]]$variants[[47]]$id #> [1] 399 #> #> $content$records[[5]]$variants[[47]]$evidence_items #> $content$records[[5]]$variants[[47]]$evidence_items$accepted_count #> [1] 11 #> #> $content$records[[5]]$variants[[47]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[47]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[5]]$aliases #> $content$records[[5]]$aliases[[1]] #> [1] "BRAF" #> #> $content$records[[5]]$aliases[[2]] #> [1] "B-raf" #> #> $content$records[[5]]$aliases[[3]] #> [1] "RAFB1" #> #> $content$records[[5]]$aliases[[4]] #> [1] "NS7" #> #> $content$records[[5]]$aliases[[5]] #> [1] "BRAF1" #> #> $content$records[[5]]$aliases[[6]] #> [1] "B-RAF1" #> #> #> $content$records[[5]]$type #> [1] "gene" #> #> #> $content$records[[6]] #> $content$records[[6]]$id #> [1] 6 #> #> $content$records[[6]]$name #> [1] "BRCA1" #> #> $content$records[[6]]$entrez_id #> [1] 672 #> #> $content$records[[6]]$description #> [1] "BRCA1 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been shown to increase the risk for these cancers, as well as prostate and pancreatic cancer. These findings have been the impetus for the increased popularity of genetic testing of healthy individuals to assess risk. Recent studies in ovarian cancer have also demonstrated that BRCA mutation status can predict treatment response. A number of trials assessing BRCA mutation status have shown an improved response to platinum agents, and more recently has led to the FDA-approval of PARP inhibitors for BRCA-positive ovarian cancers. These studies have resulted in the Society of Gynecologic Oncology to recommend germline BRCA testing in all patients with a diagnosis of ovarian cancer." #> #> $content$records[[6]]$variants #> $content$records[[6]]$variants[[1]] #> $content$records[[6]]$variants[[1]]$name #> [1] "R71K" #> #> $content$records[[6]]$variants[[1]]$id #> [1] 1241 #> #> $content$records[[6]]$variants[[1]]$evidence_items #> $content$records[[6]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[2]] #> $content$records[[6]]$variants[[2]]$name #> [1] "LOSS-OF-FUNCTION" #> #> $content$records[[6]]$variants[[2]]$id #> [1] 131 #> #> $content$records[[6]]$variants[[2]]$evidence_items #> $content$records[[6]]$variants[[2]]$evidence_items$accepted_count #> [1] 8 #> #> $content$records[[6]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[2]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[6]]$variants[[3]] #> $content$records[[6]]$variants[[3]]$name #> [1] "D1692N" #> #> $content$records[[6]]$variants[[3]]$id #> [1] 1244 #> #> $content$records[[6]]$variants[[3]]$evidence_items #> $content$records[[6]]$variants[[3]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[4]] #> $content$records[[6]]$variants[[4]]$name #> [1] "W1815X" #> #> $content$records[[6]]$variants[[4]]$id #> [1] 1555 #> #> $content$records[[6]]$variants[[4]]$evidence_items #> $content$records[[6]]$variants[[4]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[4]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[5]] #> $content$records[[6]]$variants[[5]]$name #> [1] "MUTATION" #> #> $content$records[[6]]$variants[[5]]$id #> [1] 185 #> #> $content$records[[6]]$variants[[5]]$evidence_items #> $content$records[[6]]$variants[[5]]$evidence_items$accepted_count #> [1] 15 #> #> $content$records[[6]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[5]]$evidence_items$submitted_count #> [1] 7 #> #> #> #> $content$records[[6]]$variants[[6]] #> $content$records[[6]]$variants[[6]]$name #> [1] "C61G" #> #> $content$records[[6]]$variants[[6]]$id #> [1] 1238 #> #> $content$records[[6]]$variants[[6]]$evidence_items #> $content$records[[6]]$variants[[6]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[6]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[7]] #> $content$records[[6]]$variants[[7]]$name #> [1] "M1I" #> #> $content$records[[6]]$variants[[7]]$id #> [1] 1237 #> #> $content$records[[6]]$variants[[7]]$evidence_items #> $content$records[[6]]$variants[[7]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[7]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[8]] #> $content$records[[6]]$variants[[8]]$name #> [1] "R1495M" #> #> $content$records[[6]]$variants[[8]]$id #> [1] 1242 #> #> $content$records[[6]]$variants[[8]]$evidence_items #> $content$records[[6]]$variants[[8]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[8]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[8]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[9]] #> $content$records[[6]]$variants[[9]]$name #> [1] "UNDEREXPRESSION" #> #> $content$records[[6]]$variants[[9]]$id #> [1] 403 #> #> $content$records[[6]]$variants[[9]]$evidence_items #> $content$records[[6]]$variants[[9]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[9]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[10]] #> $content$records[[6]]$variants[[10]]$name #> [1] "C64Y" #> #> $content$records[[6]]$variants[[10]]$id #> [1] 1239 #> #> $content$records[[6]]$variants[[10]]$evidence_items #> $content$records[[6]]$variants[[10]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[10]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[11]] #> $content$records[[6]]$variants[[11]]$name #> [1] "R1443*" #> #> $content$records[[6]]$variants[[11]]$id #> [1] 1245 #> #> $content$records[[6]]$variants[[11]]$evidence_items #> $content$records[[6]]$variants[[11]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[11]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[12]] #> $content$records[[6]]$variants[[12]]$name #> [1] "EXPRESSION" #> #> $content$records[[6]]$variants[[12]]$id #> [1] 397 #> #> $content$records[[6]]$variants[[12]]$evidence_items #> $content$records[[6]]$variants[[12]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[12]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[12]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[13]] #> $content$records[[6]]$variants[[13]]$name #> [1] "P968FS" #> #> $content$records[[6]]$variants[[13]]$id #> [1] 477 #> #> $content$records[[6]]$variants[[13]]$evidence_items #> $content$records[[6]]$variants[[13]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[6]]$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[13]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[14]] #> $content$records[[6]]$variants[[14]]$name #> [1] "E1559K" #> #> $content$records[[6]]$variants[[14]]$id #> [1] 1243 #> #> $content$records[[6]]$variants[[14]]$evidence_items #> $content$records[[6]]$variants[[14]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[14]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[15]] #> $content$records[[6]]$variants[[15]]$name #> [1] "R71G" #> #> $content$records[[6]]$variants[[15]]$id #> [1] 1240 #> #> $content$records[[6]]$variants[[15]]$evidence_items #> $content$records[[6]]$variants[[15]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[15]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[16]] #> $content$records[[6]]$variants[[16]]$name #> [1] "M1V" #> #> $content$records[[6]]$variants[[16]]$id #> [1] 1236 #> #> $content$records[[6]]$variants[[16]]$evidence_items #> $content$records[[6]]$variants[[16]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[16]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[17]] #> $content$records[[6]]$variants[[17]]$name #> [1] "Alu insertion" #> #> $content$records[[6]]$variants[[17]]$id #> [1] 709 #> #> $content$records[[6]]$variants[[17]]$evidence_items #> $content$records[[6]]$variants[[17]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[17]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[6]]$variants[[18]] #> $content$records[[6]]$variants[[18]]$name #> [1] "Q1467*" #> #> $content$records[[6]]$variants[[18]]$id #> [1] 1246 #> #> $content$records[[6]]$variants[[18]]$evidence_items #> $content$records[[6]]$variants[[18]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[6]]$variants[[18]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[6]]$aliases #> $content$records[[6]]$aliases[[1]] #> [1] "FANCS" #> #> $content$records[[6]]$aliases[[2]] #> [1] "PPP1R53" #> #> $content$records[[6]]$aliases[[3]] #> [1] "IRIS" #> #> $content$records[[6]]$aliases[[4]] #> [1] "PNCA4" #> #> $content$records[[6]]$aliases[[5]] #> [1] "PSCP" #> #> $content$records[[6]]$aliases[[6]] #> [1] "RNF53" #> #> $content$records[[6]]$aliases[[7]] #> [1] "BRCA1" #> #> $content$records[[6]]$aliases[[8]] #> [1] "BROVCA1" #> #> $content$records[[6]]$aliases[[9]] #> [1] "BRCC1" #> #> $content$records[[6]]$aliases[[10]] #> [1] "BRCAI" #> #> #> $content$records[[6]]$type #> [1] "gene" #> #> #> $content$records[[7]] #> $content$records[[7]]$id #> [1] 7 #> #> $content$records[[7]]$name #> [1] "BRCA2" #> #> $content$records[[7]]$entrez_id #> [1] 675 #> #> $content$records[[7]]$description #> [1] "BRCA1 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been shown to increase the risk for these cancers, as well as prostate and pancreatic cancer. These findings have been the impetus for the increased popularity of genetic testing of healthy individuals to assess risk. Recent studies in ovarian cancer have also demonstrated that BRCA mutation status can predict treatment response. A number of trials assessing BRCA mutation status have shown an improved response to platinum agents, and more recently has led to the FDA-approval of PARP inhibitors for BRCA-positive ovarian cancers. These studies have resulted in the Society of Gynecologic Oncology to recommend germline BRCA testing in all patients with a diagnosis of ovarian cancer." #> #> $content$records[[7]]$variants #> $content$records[[7]]$variants[[1]] #> $content$records[[7]]$variants[[1]]$name #> [1] "V159M" #> #> $content$records[[7]]$variants[[1]]$id #> [1] 1249 #> #> $content$records[[7]]$variants[[1]]$evidence_items #> $content$records[[7]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[2]] #> $content$records[[7]]$variants[[2]]$name #> [1] "TRUNCATING MUTATION" #> #> $content$records[[7]]$variants[[2]]$id #> [1] 708 #> #> $content$records[[7]]$variants[[2]]$evidence_items #> $content$records[[7]]$variants[[2]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[3]] #> $content$records[[7]]$variants[[3]]$name #> [1] "R2336P" #> #> $content$records[[7]]$variants[[3]]$id #> [1] 1252 #> #> $content$records[[7]]$variants[[3]]$evidence_items #> $content$records[[7]]$variants[[3]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[4]] #> $content$records[[7]]$variants[[4]]$name #> [1] "LOSS-OF-FUNCTION" #> #> $content$records[[7]]$variants[[4]]$id #> [1] 132 #> #> $content$records[[7]]$variants[[4]]$evidence_items #> $content$records[[7]]$variants[[4]]$evidence_items$accepted_count #> [1] 9 #> #> $content$records[[7]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[4]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[7]]$variants[[5]] #> $content$records[[7]]$variants[[5]]$name #> [1] "MUTATION" #> #> $content$records[[7]]$variants[[5]]$id #> [1] 186 #> #> $content$records[[7]]$variants[[5]]$evidence_items #> $content$records[[7]]$variants[[5]]$evidence_items$accepted_count #> [1] 15 #> #> $content$records[[7]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[5]]$evidence_items$submitted_count #> [1] 6 #> #> #> #> $content$records[[7]]$variants[[6]] #> $content$records[[7]]$variants[[6]]$name #> [1] "V211L" #> #> $content$records[[7]]$variants[[6]]$id #> [1] 1250 #> #> $content$records[[7]]$variants[[6]]$evidence_items #> $content$records[[7]]$variants[[6]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[6]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[7]] #> $content$records[[7]]$variants[[7]]$name #> [1] "V211I" #> #> $content$records[[7]]$variants[[7]]$id #> [1] 1251 #> #> $content$records[[7]]$variants[[7]]$evidence_items #> $content$records[[7]]$variants[[7]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[7]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[8]] #> $content$records[[7]]$variants[[8]]$name #> [1] "R2336H" #> #> $content$records[[7]]$variants[[8]]$id #> [1] 1253 #> #> $content$records[[7]]$variants[[8]]$evidence_items #> $content$records[[7]]$variants[[8]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[8]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[8]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[9]] #> $content$records[[7]]$variants[[9]]$name #> [1] "M1I" #> #> $content$records[[7]]$variants[[9]]$id #> [1] 1248 #> #> $content$records[[7]]$variants[[9]]$evidence_items #> $content$records[[7]]$variants[[9]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[9]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[10]] #> $content$records[[7]]$variants[[10]]$name #> [1] "M1R" #> #> $content$records[[7]]$variants[[10]]$id #> [1] 1247 #> #> $content$records[[7]]$variants[[10]]$evidence_items #> $content$records[[7]]$variants[[10]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[10]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[11]] #> $content$records[[7]]$variants[[11]]$name #> [1] "D3095E" #> #> $content$records[[7]]$variants[[11]]$id #> [1] 661 #> #> $content$records[[7]]$variants[[11]]$evidence_items #> $content$records[[7]]$variants[[11]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[7]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[11]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[7]]$aliases #> $content$records[[7]]$aliases[[1]] #> [1] "BRCA2" #> #> $content$records[[7]]$aliases[[2]] #> [1] "PNCA2" #> #> $content$records[[7]]$aliases[[3]] #> [1] "GLM3" #> #> $content$records[[7]]$aliases[[4]] #> [1] "FANCD1" #> #> $content$records[[7]]$aliases[[5]] #> [1] "FANCD" #> #> $content$records[[7]]$aliases[[6]] #> [1] "XRCC11" #> #> $content$records[[7]]$aliases[[7]] #> [1] "FAD1" #> #> $content$records[[7]]$aliases[[8]] #> [1] "FAD" #> #> $content$records[[7]]$aliases[[9]] #> [1] "FACD" #> #> $content$records[[7]]$aliases[[10]] #> [1] "BROVCA2" #> #> $content$records[[7]]$aliases[[11]] #> [1] "BRCC2" #> #> #> $content$records[[7]]$type #> [1] "gene" #> #> #> $content$records[[8]] #> $content$records[[8]]$id #> [1] 8 #> #> $content$records[[8]]$name #> [1] "CCND1" #> #> $content$records[[8]]$entrez_id #> [1] 595 #> #> $content$records[[8]]$description #> [1] "Cyclin D has been shown in many cancer types to be misregulated. Well established for their oncogenic properties, the cyclins, and the cyclin-dependent kinases (CDK's) they activate, have been the focus of major research and development efforts over the past decade. The methods by which the cyclins are misregulated are widely variable, ranging from genomic amplification to changes in promoter methylation. While Cyclin D2 has only been found to be significantly deregulated in glioma, Cyclin D1 seems to be a pan-cancer actor. Cyclin D misregulation has been shown to lead to poorer outcomes in a number of studies, but currently there are no FDA-approved targeted therapies." #> #> $content$records[[8]]$variants #> $content$records[[8]]$variants[[1]] #> $content$records[[8]]$variants[[1]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[8]]$variants[[1]]$id #> [1] 20 #> #> $content$records[[8]]$variants[[1]]$evidence_items #> $content$records[[8]]$variants[[1]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[8]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[2]] #> $content$records[[8]]$variants[[2]]$name #> [1] "EXPRESSION" #> #> $content$records[[8]]$variants[[2]]$id #> [1] 19 #> #> $content$records[[8]]$variants[[2]]$evidence_items #> $content$records[[8]]$variants[[2]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[3]] #> $content$records[[8]]$variants[[3]]$name #> [1] "AMPLIFICATION" #> #> $content$records[[8]]$variants[[3]]$id #> [1] 18 #> #> $content$records[[8]]$variants[[3]]$evidence_items #> $content$records[[8]]$variants[[3]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[8]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[3]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> #> $content$records[[8]]$aliases #> $content$records[[8]]$aliases[[1]] #> [1] "U21B31" #> #> $content$records[[8]]$aliases[[2]] #> [1] "BCL1" #> #> $content$records[[8]]$aliases[[3]] #> [1] "CCND1" #> #> $content$records[[8]]$aliases[[4]] #> [1] "D11S287E" #> #> $content$records[[8]]$aliases[[5]] #> [1] "PRAD1" #> #> #> $content$records[[8]]$type #> [1] "gene" #> #> #> $content$records[[9]] #> $content$records[[9]]$id #> [1] 9 #> #> $content$records[[9]]$name #> [1] "CCND2" #> #> $content$records[[9]]$entrez_id #> [1] 894 #> #> $content$records[[9]]$description #> [1] "Cyclin D has been shown in many cancer types to be misregulated. Well established for their oncogenic properties, the cyclins and the cyclin-dependent kinases (CDK's) they activate have been the focus of major research and development efforts over the past decade. The methods by which the cyclins are misregulated are widely variable, ranging from genomic amplification to changes in promoter methylation. While Cyclin D2 has only been found to be significantly deregulated in glioma, Cyclin D1 in particular seems to be a pan-cancer actor. Cyclin D misregulation has been shown to lead to poorer outcomes in a number of studies, and currently there are no FDA-approved targeted therapies." #> #> $content$records[[9]]$variants #> $content$records[[9]]$variants[[1]] #> $content$records[[9]]$variants[[1]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[9]]$variants[[1]]$id #> [1] 21 #> #> $content$records[[9]]$variants[[1]]$evidence_items #> $content$records[[9]]$variants[[1]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[9]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[2]] #> $content$records[[9]]$variants[[2]]$name #> [1] "PROMOTER DEMETHYLATION" #> #> $content$records[[9]]$variants[[2]]$id #> [1] 22 #> #> $content$records[[9]]$variants[[2]]$evidence_items #> $content$records[[9]]$variants[[2]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[9]]$aliases #> $content$records[[9]]$aliases[[1]] #> [1] "CCND2" #> #> $content$records[[9]]$aliases[[2]] #> [1] "MPPH3" #> #> $content$records[[9]]$aliases[[3]] #> [1] "KIAK0002" #> #> #> $content$records[[9]]$type #> [1] "gene" #> #> #> $content$records[[10]] #> $content$records[[10]]$id #> [1] 10 #> #> $content$records[[10]]$name #> [1] "CCND3" #> #> $content$records[[10]]$entrez_id #> [1] 896 #> #> $content$records[[10]]$description #> [1] "Cyclin D has been shown in many cancer types to be misregulated. Well established for their oncogenic properties, the cyclins and the cyclin-dependent kinases (CDK's) they activate have been the focus of major research and development efforts over the past decade. The methods by which the cyclins are misregulated are widely variable, ranging from genomic amplification to changes in promoter methylation. Cyclin D3 loss has been reported in T-ALL, a seemingly unique trend when compared to the amplifcations and overexpressions of the other cyclin D's. In a mouse study, the targeted therapeutic palbociclib significantly increased the median survival of the cyclin D3 knockouts." #> #> $content$records[[10]]$variants #> $content$records[[10]]$variants[[1]] #> $content$records[[10]]$variants[[1]]$name #> [1] "LOSS" #> #> $content$records[[10]]$variants[[1]]$id #> [1] 23 #> #> $content$records[[10]]$variants[[1]]$evidence_items #> $content$records[[10]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[10]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[10]]$aliases #> $content$records[[10]]$aliases[[1]] #> [1] "CCND3" #> #> #> $content$records[[10]]$type #> [1] "gene" #> #> #> #> #> $url #> [1] "https://civicdb.org/api/genes" #> #> $response #> Response [https://civicdb.org/api/genes?page=1&count=10] #> Date: 2019-09-03 16:44 #> Status: 200 #> Content-Type: application/json; charset=utf-8 #> Size: 26.8 kB #> #> #> attr(,"class") #> [1] "civic_api"getAllGenes(page = 2, count = 10)#> $content #> $content$`_meta` #> $content$`_meta`$current_page #> [1] 2 #> #> $content$`_meta`$per_page #> [1] "10" #> #> $content$`_meta`$total_pages #> [1] 32 #> #> $content$`_meta`$total_count #> [1] 313 #> #> $content$`_meta`$links #> $content$`_meta`$links$`next` #> [1] "https://civicdb.org/api/genes?count=10&page=3" #> #> $content$`_meta`$links$previous #> [1] "https://civicdb.org/api/genes?count=10&page=1" #> #> #> #> $content$records #> $content$records[[1]] #> $content$records[[1]]$id #> [1] 11 #> #> $content$records[[1]]$name #> [1] "CCNE1" #> #> $content$records[[1]]$entrez_id #> [1] 898 #> #> $content$records[[1]]$description #> [1] "Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts." #> #> $content$records[[1]]$variants #> $content$records[[1]]$variants[[1]] #> $content$records[[1]]$variants[[1]]$name #> [1] "AMPLIFICATION" #> #> $content$records[[1]]$variants[[1]]$id #> [1] 187 #> #> $content$records[[1]]$variants[[1]]$evidence_items #> $content$records[[1]]$variants[[1]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[1]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[1]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[1]]$variants[[2]] #> $content$records[[1]]$variants[[2]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[1]]$variants[[2]]$id #> [1] 24 #> #> $content$records[[1]]$variants[[2]]$evidence_items #> $content$records[[1]]$variants[[2]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[1]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[1]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[1]]$aliases #> $content$records[[1]]$aliases[[1]] #> [1] "pCCNE1" #> #> $content$records[[1]]$aliases[[2]] #> [1] "CCNE" #> #> $content$records[[1]]$aliases[[3]] #> [1] "CCNE1" #> #> #> $content$records[[1]]$type #> [1] "gene" #> #> #> $content$records[[2]] #> $content$records[[2]]$id #> [1] 12 #> #> $content$records[[2]]$name #> [1] "CDK6" #> #> $content$records[[2]]$entrez_id #> [1] 1021 #> #> $content$records[[2]]$description #> [1] "CDK6, along with its partner CDK4, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors." #> #> $content$records[[2]]$variants #> $content$records[[2]]$variants[[1]] #> $content$records[[2]]$variants[[1]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[2]]$variants[[1]]$id #> [1] 602 #> #> $content$records[[2]]$variants[[1]]$evidence_items #> $content$records[[2]]$variants[[1]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[2]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[2]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[2]]$aliases #> $content$records[[2]]$aliases[[1]] #> [1] "CDK6" #> #> $content$records[[2]]$aliases[[2]] #> [1] "MCPH12" #> #> $content$records[[2]]$aliases[[3]] #> [1] "PLSTIRE" #> #> #> $content$records[[2]]$type #> [1] "gene" #> #> #> $content$records[[3]] #> $content$records[[3]]$id #> [1] 13 #> #> $content$records[[3]]$name #> [1] "CDK4" #> #> $content$records[[3]]$entrez_id #> [1] 1019 #> #> $content$records[[3]]$description #> [1] "CDK4, along with its partner CDK6, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors." #> #> $content$records[[3]]$variants #> $content$records[[3]]$variants[[1]] #> $content$records[[3]]$variants[[1]]$name #> [1] "R24C" #> #> $content$records[[3]]$variants[[1]]$id #> [1] 556 #> #> $content$records[[3]]$variants[[1]]$evidence_items #> $content$records[[3]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[3]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[3]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[3]]$variants[[2]] #> $content$records[[3]]$variants[[2]]$name #> [1] "AMPLIFICATION" #> #> $content$records[[3]]$variants[[2]]$id #> [1] 553 #> #> $content$records[[3]]$variants[[2]]$evidence_items #> $content$records[[3]]$variants[[2]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[3]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[3]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[3]]$variants[[3]] #> $content$records[[3]]$variants[[3]]$name #> [1] "EXPRESSION" #> #> $content$records[[3]]$variants[[3]]$id #> [1] 25 #> #> $content$records[[3]]$variants[[3]]$evidence_items #> $content$records[[3]]$variants[[3]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[3]]$variants[[3]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[3]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[3]]$aliases #> $content$records[[3]]$aliases[[1]] #> [1] "CDK4" #> #> $content$records[[3]]$aliases[[2]] #> [1] "PSK-J3" #> #> $content$records[[3]]$aliases[[3]] #> [1] "CMM3" #> #> #> $content$records[[3]]$type #> [1] "gene" #> #> #> $content$records[[4]] #> $content$records[[4]]$id #> [1] 14 #> #> $content$records[[4]]$name #> [1] "CDKN2A" #> #> $content$records[[4]]$entrez_id #> [1] 1029 #> #> $content$records[[4]]$description #> [1] "CDKN2A loss has been shown to be a significant event in a number of cancer types. While no targeted therapeutic has been engaged in clinical trials, the prognostic impact has been studied by a number of meta-analyses. In majority of cases CDKN2A is inactivated by homozygous deletions. One of the mechanisms by which loss of CDKN2A can occur is by hypermethylation of the promoter region for the gene. However, the prognostic impact of promoter hypermethylation has been relatively ambiguous. Many studies have suggesting poorer prognostic outcome for patients with hypermethylation in colorectal, liver, and younger lung cancer patients. This being said, there is still research to be done before this becomes a widely-accepted prognostic indicator.\nAdditionally, CDKN2A (p16) expression is a surrogate marker for HPV infection. As such, CDKN2A expression is prognostic in Oropharyngeal and probably also non-oropharyngeal head and neck squamous cell carcinomas." #> #> $content$records[[4]]$variants #> $content$records[[4]]$variants[[1]] #> $content$records[[4]]$variants[[1]]$name #> [1] "RS3814960" #> #> $content$records[[4]]$variants[[1]]$id #> [1] 641 #> #> $content$records[[4]]$variants[[1]]$evidence_items #> $content$records[[4]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[4]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[2]] #> $content$records[[4]]$variants[[2]]$name #> [1] "LOSS" #> #> $content$records[[4]]$variants[[2]]$id #> [1] 554 #> #> $content$records[[4]]$variants[[2]]$evidence_items #> $content$records[[4]]$variants[[2]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[4]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[2]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[4]]$variants[[3]] #> $content$records[[4]]$variants[[3]]$name #> [1] "p16 EXPRESSION" #> #> $content$records[[4]]$variants[[3]]$id #> [1] 272 #> #> $content$records[[4]]$variants[[3]]$evidence_items #> $content$records[[4]]$variants[[3]]$evidence_items$accepted_count #> [1] 10 #> #> $content$records[[4]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[3]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[4]]$variants[[4]] #> $content$records[[4]]$variants[[4]]$name #> [1] "MUTATION" #> #> $content$records[[4]]$variants[[4]]$id #> [1] 2704 #> #> $content$records[[4]]$variants[[4]]$evidence_items #> $content$records[[4]]$variants[[4]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[4]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[4]]$variants[[5]] #> $content$records[[4]]$variants[[5]]$name #> [1] "PROMOTER HYPERMETHYLATION" #> #> $content$records[[4]]$variants[[5]]$id #> [1] 27 #> #> $content$records[[4]]$variants[[5]]$evidence_items #> $content$records[[4]]$variants[[5]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[4]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[4]]$variants[[5]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[4]]$aliases #> $content$records[[4]]$aliases[[1]] #> [1] "CDKN2A" #> #> $content$records[[4]]$aliases[[2]] #> [1] "TP16" #> #> $content$records[[4]]$aliases[[3]] #> [1] "ARF" #> #> $content$records[[4]]$aliases[[4]] #> [1] "INK4A" #> #> $content$records[[4]]$aliases[[5]] #> [1] "MLM" #> #> $content$records[[4]]$aliases[[6]] #> [1] "MTS-1" #> #> $content$records[[4]]$aliases[[7]] #> [1] "MTS1" #> #> $content$records[[4]]$aliases[[8]] #> [1] "P14" #> #> $content$records[[4]]$aliases[[9]] #> [1] "P14ARF" #> #> $content$records[[4]]$aliases[[10]] #> [1] "P16" #> #> $content$records[[4]]$aliases[[11]] #> [1] "P16-INK4A" #> #> $content$records[[4]]$aliases[[12]] #> [1] "P16INK4" #> #> $content$records[[4]]$aliases[[13]] #> [1] "P16INK4A" #> #> $content$records[[4]]$aliases[[14]] #> [1] "P19ARF" #> #> $content$records[[4]]$aliases[[15]] #> [1] "P19" #> #> $content$records[[4]]$aliases[[16]] #> [1] "CDK4I" #> #> $content$records[[4]]$aliases[[17]] #> [1] "CDKN2" #> #> $content$records[[4]]$aliases[[18]] #> [1] "CMM2" #> #> $content$records[[4]]$aliases[[19]] #> [1] "INK4" #> #> #> $content$records[[4]]$type #> [1] "gene" #> #> #> $content$records[[5]] #> $content$records[[5]]$id #> [1] 15 #> #> $content$records[[5]]$name #> [1] "CEBPA" #> #> $content$records[[5]]$entrez_id #> [1] 1050 #> #> $content$records[[5]]$description #> [1] "'AML with mutated CEBPA' is a provisional entity in the WHO classification of acute myeloid leukemia (AML) and is recommended to be tested for in patients with AML. CEBPA mutations are particularly associated with cytogenetically normal AML (CN-AML). CEBPA is an intronless gene that is required for granulocyte formation in mice. N-terminal nonsense mutations result in a dominant negative C/EBP-alpha protein while C-terminal mutations reduce the DNA-binding potential of this transcription factor. CEBPA mutations are associated with a favorable prognosis, however, NPM1 and FLT3 mutations should also be assessed in CN-AML patients as concurrent mutations may have prognostic implications." #> #> $content$records[[5]]$variants #> $content$records[[5]]$variants[[1]] #> $content$records[[5]]$variants[[1]]$name #> [1] "BIALLELIC INACTIVATION" #> #> $content$records[[5]]$variants[[1]]$id #> [1] 594 #> #> $content$records[[5]]$variants[[1]]$evidence_items #> $content$records[[5]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[5]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[2]] #> $content$records[[5]]$variants[[2]]$name #> [1] "N-TERMINAL FRAME SHIFT" #> #> $content$records[[5]]$variants[[2]]$id #> [1] 28 #> #> $content$records[[5]]$variants[[2]]$evidence_items #> $content$records[[5]]$variants[[2]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[5]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[5]]$variants[[3]] #> $content$records[[5]]$variants[[3]]$name #> [1] "MUTATION" #> #> $content$records[[5]]$variants[[3]]$id #> [1] 29 #> #> $content$records[[5]]$variants[[3]]$evidence_items #> $content$records[[5]]$variants[[3]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[5]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[5]]$variants[[3]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[5]]$aliases #> $content$records[[5]]$aliases[[1]] #> [1] "CEBPA" #> #> $content$records[[5]]$aliases[[2]] #> [1] "C/EBP-alpha" #> #> $content$records[[5]]$aliases[[3]] #> [1] "CEBP" #> #> #> $content$records[[5]]$type #> [1] "gene" #> #> #> $content$records[[6]] #> $content$records[[6]]$id #> [1] 17 #> #> $content$records[[6]]$name #> [1] "PRKACA" #> #> $content$records[[6]]$entrez_id #> [1] 5566 #> #> $content$records[[6]]$description #> [1] "PRKACA has been studied in breast cancer and has been found to mediate resistance to HER2 targeted therapies. It has also been found to contain a mutation hotspot that contributes to neoplastic behavior in neuroendocrine cancers. In hepatocellular fibrolamellar carcinoma (FL-HCC), the fusion DNAJB1 to PRKACA is suggested to be a diagnostic marker for this rare subtype of HCC. In one study, this fusion was observed in 15/15 FL-HCC cases examined and functional studies found that the fusion retained kinase activity." #> #> $content$records[[6]]$variants #> $content$records[[6]]$variants[[1]] #> $content$records[[6]]$variants[[1]]$name #> [1] "DNAJB1-PRKACA" #> #> $content$records[[6]]$variants[[1]]$id #> [1] 31 #> #> $content$records[[6]]$variants[[1]]$evidence_items #> $content$records[[6]]$variants[[1]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[6]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[6]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[6]]$aliases #> $content$records[[6]]$aliases[[1]] #> [1] "PRKACA" #> #> $content$records[[6]]$aliases[[2]] #> [1] "PPNAD4" #> #> $content$records[[6]]$aliases[[3]] #> [1] "PKACA" #> #> #> $content$records[[6]]$type #> [1] "gene" #> #> #> $content$records[[7]] #> $content$records[[7]]$id #> [1] 18 #> #> $content$records[[7]]$name #> [1] "DNMT3A" #> #> $content$records[[7]]$entrez_id #> [1] 1788 #> #> $content$records[[7]]$description #> [1] "DNMT3A is one of several epigenetic modifiers identified as recurrently mutated in acute myeloid leukemia (AML). DNMT3A mutations are associated with cytogenetically normal AML. In vitro experiments indicate that the R882H mutation acts in a dominant negative manner to disrupt the de novo methyltransferase activity of wildtype homotetramers. AML patient bone marrow harboring R882 mutations were similarly demonstrated to be hypomethylated compared to patients with wildtype DNMT3A. These studies also indicated that non-R882 DNMT3A mutations may act in a functionally distinct manner from R882 mutations. Alternative mechanisms indicate independent prognostic outcomes and treatment protocols may need to be considered for these two classes of DNMT3A mutations." #> #> $content$records[[7]]$variants #> $content$records[[7]]$variants[[1]] #> $content$records[[7]]$variants[[1]]$name #> [1] "R882" #> #> $content$records[[7]]$variants[[1]]$id #> [1] 32 #> #> $content$records[[7]]$variants[[1]]$evidence_items #> $content$records[[7]]$variants[[1]]$evidence_items$accepted_count #> [1] 28 #> #> $content$records[[7]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[7]]$variants[[2]] #> $content$records[[7]]$variants[[2]]$name #> [1] "MUTATION" #> #> $content$records[[7]]$variants[[2]]$id #> [1] 189 #> #> $content$records[[7]]$variants[[2]]$evidence_items #> $content$records[[7]]$variants[[2]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[7]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[7]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[7]]$aliases #> $content$records[[7]]$aliases[[1]] #> [1] "DNMT3A2" #> #> $content$records[[7]]$aliases[[2]] #> [1] "M.HsaIIIA" #> #> $content$records[[7]]$aliases[[3]] #> [1] "TBRS" #> #> $content$records[[7]]$aliases[[4]] #> [1] "DNMT3A" #> #> #> $content$records[[7]]$type #> [1] "gene" #> #> #> $content$records[[8]] #> $content$records[[8]]$id #> [1] 19 #> #> $content$records[[8]]$name #> [1] "EGFR" #> #> $content$records[[8]]$entrez_id #> [1] 1956 #> #> $content$records[[8]]$description #> [1] "EGFR is widely recognized for its importance in cancer. Amplification and mutations have been shown to be driving events in many cancer types. Its role in non-small cell lung cancer, glioblastoma and basal-like breast cancers has spurred many research and drug development efforts. Tyrosine kinase inhibitors have shown efficacy in EGFR amplfied tumors, most notably gefitinib and erlotinib. Mutations in EGFR have been shown to confer resistance to these drugs, particularly the variant T790M, which has been functionally characterized as a resistance marker for both of these drugs. The later generation TKI's have seen some success in treating these resistant cases, and targeted sequencing of the EGFR locus has become a common practice in treatment of non-small cell lung cancer. \nOverproduction of ligands is another possible mechanism of activation of EGFR. ERBB ligands include EGF, TGF-a, AREG, EPG, BTC, HB-EGF, EPR and NRG1-4 (for detailed information please refer to the respective ligand section). In ligand-activated cancers, Cetuximab appears to be more effective than tyrosine-kinase inhibitors (Arteaga et. al.)." #> #> $content$records[[8]]$variants #> $content$records[[8]]$variants[[1]] #> $content$records[[8]]$variants[[1]]$name #> [1] "L747_P753delinsS" #> #> $content$records[[8]]$variants[[1]]$id #> [1] 1012 #> #> $content$records[[8]]$variants[[1]]$evidence_items #> $content$records[[8]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[1]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[8]]$variants[[2]] #> $content$records[[8]]$variants[[2]]$name #> [1] "S768I" #> #> $content$records[[8]]$variants[[2]]$id #> [1] 562 #> #> $content$records[[8]]$variants[[2]]$evidence_items #> $content$records[[8]]$variants[[2]]$evidence_items$accepted_count #> [1] 5 #> #> $content$records[[8]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[2]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[8]]$variants[[3]] #> $content$records[[8]]$variants[[3]]$name #> [1] "C797S" #> #> $content$records[[8]]$variants[[3]]$id #> [1] 415 #> #> $content$records[[8]]$variants[[3]]$evidence_items #> $content$records[[8]]$variants[[3]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[3]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[4]] #> $content$records[[8]]$variants[[4]]$name #> [1] "RARE EGRF MUT" #> #> $content$records[[8]]$variants[[4]]$id #> [1] 2334 #> #> $content$records[[8]]$variants[[4]]$evidence_items #> $content$records[[8]]$variants[[4]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[4]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[5]] #> $content$records[[8]]$variants[[5]]$name #> [1] "Ex19 del L858R" #> #> $content$records[[8]]$variants[[5]]$id #> [1] 1854 #> #> $content$records[[8]]$variants[[5]]$evidence_items #> $content$records[[8]]$variants[[5]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[8]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[5]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[6]] #> $content$records[[8]]$variants[[6]]$name #> [1] "T785A" #> #> $content$records[[8]]$variants[[6]]$id #> [1] 1573 #> #> $content$records[[8]]$variants[[6]]$evidence_items #> $content$records[[8]]$variants[[6]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[6]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[7]] #> $content$records[[8]]$variants[[7]]$name #> [1] "N826Y" #> #> $content$records[[8]]$variants[[7]]$id #> [1] 1896 #> #> $content$records[[8]]$variants[[7]]$evidence_items #> $content$records[[8]]$variants[[7]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[7]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[8]] #> $content$records[[8]]$variants[[8]]$name #> [1] "MUTATION" #> #> $content$records[[8]]$variants[[8]]$id #> [1] 442 #> #> $content$records[[8]]$variants[[8]]$evidence_items #> $content$records[[8]]$variants[[8]]$evidence_items$accepted_count #> [1] 13 #> #> $content$records[[8]]$variants[[8]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[8]]$variants[[8]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[8]]$variants[[9]] #> $content$records[[8]]$variants[[9]]$name #> [1] "G724S" #> #> $content$records[[8]]$variants[[9]]$id #> [1] 317 #> #> $content$records[[8]]$variants[[9]]$evidence_items #> $content$records[[8]]$variants[[9]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[9]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[10]] #> $content$records[[8]]$variants[[10]]$name #> [1] "L838P" #> #> $content$records[[8]]$variants[[10]]$id #> [1] 1457 #> #> $content$records[[8]]$variants[[10]]$evidence_items #> $content$records[[8]]$variants[[10]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[10]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[10]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[11]] #> $content$records[[8]]$variants[[11]]$name #> [1] "L861R" #> #> $content$records[[8]]$variants[[11]]$id #> [1] 1477 #> #> $content$records[[8]]$variants[[11]]$evidence_items #> $content$records[[8]]$variants[[11]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[11]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[12]] #> $content$records[[8]]$variants[[12]]$name #> [1] "G465R" #> #> $content$records[[8]]$variants[[12]]$id #> [1] 443 #> #> $content$records[[8]]$variants[[12]]$evidence_items #> $content$records[[8]]$variants[[12]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[12]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[12]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[13]] #> $content$records[[8]]$variants[[13]]$name #> [1] "Y764_V765insHH" #> #> $content$records[[8]]$variants[[13]]$id #> [1] 1665 #> #> $content$records[[8]]$variants[[13]]$evidence_items #> $content$records[[8]]$variants[[13]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[13]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[14]] #> $content$records[[8]]$variants[[14]]$name #> [1] "V834I" #> #> $content$records[[8]]$variants[[14]]$id #> [1] 1897 #> #> $content$records[[8]]$variants[[14]]$evidence_items #> $content$records[[8]]$variants[[14]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[14]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[15]] #> $content$records[[8]]$variants[[15]]$name #> [1] "EXON 4 DELETION" #> #> $content$records[[8]]$variants[[15]]$id #> [1] 252 #> #> $content$records[[8]]$variants[[15]]$evidence_items #> $content$records[[8]]$variants[[15]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[15]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[16]] #> $content$records[[8]]$variants[[16]]$name #> [1] "T263P" #> #> $content$records[[8]]$variants[[16]]$id #> [1] 995 #> #> $content$records[[8]]$variants[[16]]$evidence_items #> $content$records[[8]]$variants[[16]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[16]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[17]] #> $content$records[[8]]$variants[[17]]$name #> [1] "D761Y" #> #> $content$records[[8]]$variants[[17]]$id #> [1] 712 #> #> $content$records[[8]]$variants[[17]]$evidence_items #> $content$records[[8]]$variants[[17]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[17]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[18]] #> $content$records[[8]]$variants[[18]]$name #> [1] "K757R" #> #> $content$records[[8]]$variants[[18]]$id #> [1] 723 #> #> $content$records[[8]]$variants[[18]]$evidence_items #> $content$records[[8]]$variants[[18]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[18]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[19]] #> $content$records[[8]]$variants[[19]]$name #> [1] "G719" #> #> $content$records[[8]]$variants[[19]]$id #> [1] 718 #> #> $content$records[[8]]$variants[[19]]$evidence_items #> $content$records[[8]]$variants[[19]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[19]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[19]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[20]] #> $content$records[[8]]$variants[[20]]$name #> [1] "Y801H" #> #> $content$records[[8]]$variants[[20]]$id #> [1] 1575 #> #> $content$records[[8]]$variants[[20]]$evidence_items #> $content$records[[8]]$variants[[20]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[20]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[20]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[21]] #> $content$records[[8]]$variants[[21]]$name #> [1] "R831H" #> #> $content$records[[8]]$variants[[21]]$id #> [1] 1017 #> #> $content$records[[8]]$variants[[21]]$evidence_items #> $content$records[[8]]$variants[[21]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[21]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[21]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[8]]$variants[[22]] #> $content$records[[8]]$variants[[22]]$name #> [1] "R776C" #> #> $content$records[[8]]$variants[[22]]$id #> [1] 1181 #> #> $content$records[[8]]$variants[[22]]$evidence_items #> $content$records[[8]]$variants[[22]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[22]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[22]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[23]] #> $content$records[[8]]$variants[[23]]$name #> [1] "L838V" #> #> $content$records[[8]]$variants[[23]]$id #> [1] 1018 #> #> $content$records[[8]]$variants[[23]]$evidence_items #> $content$records[[8]]$variants[[23]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[23]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[23]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[24]] #> $content$records[[8]]$variants[[24]]$name #> [1] "WILDTYPE" #> #> $content$records[[8]]$variants[[24]]$id #> [1] 2174 #> #> $content$records[[8]]$variants[[24]]$evidence_items #> $content$records[[8]]$variants[[24]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[24]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[8]]$variants[[24]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[25]] #> $content$records[[8]]$variants[[25]]$name #> [1] "VIII" #> #> $content$records[[8]]$variants[[25]]$id #> [1] 312 #> #> $content$records[[8]]$variants[[25]]$evidence_items #> $content$records[[8]]$variants[[25]]$evidence_items$accepted_count #> [1] 7 #> #> $content$records[[8]]$variants[[25]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[25]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[26]] #> $content$records[[8]]$variants[[26]]$name #> [1] "Y1092 PHOSPHORYLATION" #> #> $content$records[[8]]$variants[[26]]$id #> [1] 390 #> #> $content$records[[8]]$variants[[26]]$evidence_items #> $content$records[[8]]$variants[[26]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[26]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[26]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[27]] #> $content$records[[8]]$variants[[27]]$name #> [1] "G719S" #> #> $content$records[[8]]$variants[[27]]$id #> [1] 134 #> #> $content$records[[8]]$variants[[27]]$evidence_items #> $content$records[[8]]$variants[[27]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[8]]$variants[[27]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[27]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[8]]$variants[[28]] #> $content$records[[8]]$variants[[28]]$name #> [1] "L747P" #> #> $content$records[[8]]$variants[[28]]$id #> [1] 1891 #> #> $content$records[[8]]$variants[[28]]$evidence_items #> $content$records[[8]]$variants[[28]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[28]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[28]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[29]] #> $content$records[[8]]$variants[[29]]$name #> [1] "S720" #> #> $content$records[[8]]$variants[[29]]$id #> [1] 720 #> #> $content$records[[8]]$variants[[29]]$evidence_items #> $content$records[[8]]$variants[[29]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[29]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[29]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[30]] #> $content$records[[8]]$variants[[30]]$name #> [1] "D770_N771insGT" #> #> $content$records[[8]]$variants[[30]]$id #> [1] 1566 #> #> $content$records[[8]]$variants[[30]]$evidence_items #> $content$records[[8]]$variants[[30]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[30]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[30]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[31]] #> $content$records[[8]]$variants[[31]]$name #> [1] "EXPRESSION" #> #> $content$records[[8]]$variants[[31]]$id #> [1] 354 #> #> $content$records[[8]]$variants[[31]]$evidence_items #> $content$records[[8]]$variants[[31]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[8]]$variants[[31]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[31]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[8]]$variants[[32]] #> $content$records[[8]]$variants[[32]]$name #> [1] "EXON 20 INSERTION" #> #> $content$records[[8]]$variants[[32]]$id #> [1] 726 #> #> $content$records[[8]]$variants[[32]]$evidence_items #> $content$records[[8]]$variants[[32]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[32]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[32]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[8]]$variants[[33]] #> $content$records[[8]]$variants[[33]]$name #> [1] "V774M" #> #> $content$records[[8]]$variants[[33]]$id #> [1] 1894 #> #> $content$records[[8]]$variants[[33]]$evidence_items #> $content$records[[8]]$variants[[33]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[33]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[33]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[34]] #> $content$records[[8]]$variants[[34]]$name #> [1] "V851I" #> #> $content$records[[8]]$variants[[34]]$id #> [1] 1466 #> #> $content$records[[8]]$variants[[34]]$evidence_items #> $content$records[[8]]$variants[[34]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[34]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[34]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[35]] #> $content$records[[8]]$variants[[35]]$name #> [1] "S492R" #> #> $content$records[[8]]$variants[[35]]$id #> [1] 453 #> #> $content$records[[8]]$variants[[35]]$evidence_items #> $content$records[[8]]$variants[[35]]$evidence_items$accepted_count #> [1] 4 #> #> $content$records[[8]]$variants[[35]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[35]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[36]] #> $content$records[[8]]$variants[[36]]$name #> [1] "H773_V774insNPH" #> #> $content$records[[8]]$variants[[36]]$id #> [1] 1513 #> #> $content$records[[8]]$variants[[36]]$evidence_items #> $content$records[[8]]$variants[[36]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[36]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[36]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[37]] #> $content$records[[8]]$variants[[37]]$name #> [1] "K467T" #> #> $content$records[[8]]$variants[[37]]$id #> [1] 455 #> #> $content$records[[8]]$variants[[37]]$evidence_items #> $content$records[[8]]$variants[[37]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[37]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[37]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[38]] #> $content$records[[8]]$variants[[38]]$name #> [1] "G719D" #> #> $content$records[[8]]$variants[[38]]$id #> [1] 1420 #> #> $content$records[[8]]$variants[[38]]$evidence_items #> $content$records[[8]]$variants[[38]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[38]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[38]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[39]] #> $content$records[[8]]$variants[[39]]$name #> [1] "L858R" #> #> $content$records[[8]]$variants[[39]]$id #> [1] 33 #> #> $content$records[[8]]$variants[[39]]$evidence_items #> $content$records[[8]]$variants[[39]]$evidence_items$accepted_count #> [1] 37 #> #> $content$records[[8]]$variants[[39]]$evidence_items$rejected_count #> [1] 1 #> #> $content$records[[8]]$variants[[39]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[8]]$variants[[40]] #> $content$records[[8]]$variants[[40]]$name #> [1] "N826S" #> #> $content$records[[8]]$variants[[40]]$id #> [1] 1188 #> #> $content$records[[8]]$variants[[40]]$evidence_items #> $content$records[[8]]$variants[[40]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[40]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[40]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[41]] #> $content$records[[8]]$variants[[41]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[8]]$variants[[41]]$id #> [1] 193 #> #> $content$records[[8]]$variants[[41]]$evidence_items #> $content$records[[8]]$variants[[41]]$evidence_items$accepted_count #> [1] 8 #> #> $content$records[[8]]$variants[[41]]$evidence_items$rejected_count #> [1] 2 #> #> $content$records[[8]]$variants[[41]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[8]]$variants[[42]] #> $content$records[[8]]$variants[[42]]$name #> [1] "R705K" #> #> $content$records[[8]]$variants[[42]]$id #> [1] 2333 #> #> $content$records[[8]]$variants[[42]]$evidence_items #> $content$records[[8]]$variants[[42]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[42]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[42]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[43]] #> $content$records[[8]]$variants[[43]]$name #> [1] "T847I" #> #> $content$records[[8]]$variants[[43]]$id #> [1] 1463 #> #> $content$records[[8]]$variants[[43]]$evidence_items #> $content$records[[8]]$variants[[43]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[43]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[43]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[44]] #> $content$records[[8]]$variants[[44]]$name #> [1] "V774A" #> #> $content$records[[8]]$variants[[44]]$id #> [1] 1892 #> #> $content$records[[8]]$variants[[44]]$evidence_items #> $content$records[[8]]$variants[[44]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[44]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[44]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[45]] #> $content$records[[8]]$variants[[45]]$name #> [1] "V769_770insASV" #> #> $content$records[[8]]$variants[[45]]$id #> [1] 736 #> #> $content$records[[8]]$variants[[45]]$evidence_items #> $content$records[[8]]$variants[[45]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[45]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[45]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[8]]$variants[[46]] #> $content$records[[8]]$variants[[46]]$name #> [1] "E746G" #> #> $content$records[[8]]$variants[[46]]$id #> [1] 724 #> #> $content$records[[8]]$variants[[46]]$evidence_items #> $content$records[[8]]$variants[[46]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[46]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[46]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[47]] #> $content$records[[8]]$variants[[47]]$name #> [1] "G719A" #> #> $content$records[[8]]$variants[[47]]$id #> [1] 999 #> #> $content$records[[8]]$variants[[47]]$evidence_items #> $content$records[[8]]$variants[[47]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[47]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[47]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[8]]$variants[[48]] #> $content$records[[8]]$variants[[48]]$name #> [1] "A767_V769dupASV" #> #> $content$records[[8]]$variants[[48]]$id #> [1] 1579 #> #> $content$records[[8]]$variants[[48]]$evidence_items #> $content$records[[8]]$variants[[48]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[48]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[48]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[8]]$variants[[49]] #> $content$records[[8]]$variants[[49]]$name #> [1] "D770_N771insSVD" #> #> $content$records[[8]]$variants[[49]]$id #> [1] 1445 #> #> $content$records[[8]]$variants[[49]]$evidence_items #> $content$records[[8]]$variants[[49]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[49]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[49]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[8]]$variants[[50]] #> $content$records[[8]]$variants[[50]]$name #> [1] "P772_V774insPHV" #> #> $content$records[[8]]$variants[[50]]$id #> [1] 1668 #> #> $content$records[[8]]$variants[[50]]$evidence_items #> $content$records[[8]]$variants[[50]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[50]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[50]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[51]] #> $content$records[[8]]$variants[[51]]$name #> [1] "K806E" #> #> $content$records[[8]]$variants[[51]]$id #> [1] 1895 #> #> $content$records[[8]]$variants[[51]]$evidence_items #> $content$records[[8]]$variants[[51]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[51]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[51]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[52]] #> $content$records[[8]]$variants[[52]]$name #> [1] "L861" #> #> $content$records[[8]]$variants[[52]]$id #> [1] 1866 #> #> $content$records[[8]]$variants[[52]]$evidence_items #> $content$records[[8]]$variants[[52]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[52]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[52]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[53]] #> $content$records[[8]]$variants[[53]]$name #> [1] "A763_Y764insFQEA" #> #> $content$records[[8]]$variants[[53]]$id #> [1] 1515 #> #> $content$records[[8]]$variants[[53]]$evidence_items #> $content$records[[8]]$variants[[53]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[53]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[53]]$evidence_items$submitted_count #> [1] 4 #> #> #> #> $content$records[[8]]$variants[[54]] #> $content$records[[8]]$variants[[54]]$name #> [1] "EXON 18 OVEREXPRESSION" #> #> $content$records[[8]]$variants[[54]]$id #> [1] 375 #> #> $content$records[[8]]$variants[[54]]$evidence_items #> $content$records[[8]]$variants[[54]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[54]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[54]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[55]] #> $content$records[[8]]$variants[[55]]$name #> [1] "E868G" #> #> $content$records[[8]]$variants[[55]]$id #> [1] 1482 #> #> $content$records[[8]]$variants[[55]]$evidence_items #> $content$records[[8]]$variants[[55]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[55]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[55]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[56]] #> $content$records[[8]]$variants[[56]]$name #> [1] "A289V" #> #> $content$records[[8]]$variants[[56]]$id #> [1] 996 #> #> $content$records[[8]]$variants[[56]]$evidence_items #> $content$records[[8]]$variants[[56]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[56]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[56]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[57]] #> $content$records[[8]]$variants[[57]]$name #> [1] "COPY NUMBER VARIATION" #> #> $content$records[[8]]$variants[[57]]$id #> [1] 191 #> #> $content$records[[8]]$variants[[57]]$evidence_items #> $content$records[[8]]$variants[[57]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[8]]$variants[[57]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[57]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[58]] #> $content$records[[8]]$variants[[58]]$name #> [1] "N842S" #> #> $content$records[[8]]$variants[[58]]$id #> [1] 1899 #> #> $content$records[[8]]$variants[[58]]$evidence_items #> $content$records[[8]]$variants[[58]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[58]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[58]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[59]] #> $content$records[[8]]$variants[[59]]$name #> [1] "T790M" #> #> $content$records[[8]]$variants[[59]]$id #> [1] 34 #> #> $content$records[[8]]$variants[[59]]$evidence_items #> $content$records[[8]]$variants[[59]]$evidence_items$accepted_count #> [1] 30 #> #> $content$records[[8]]$variants[[59]]$evidence_items$rejected_count #> [1] 2 #> #> $content$records[[8]]$variants[[59]]$evidence_items$submitted_count #> [1] 8 #> #> #> #> $content$records[[8]]$variants[[60]] #> $content$records[[8]]$variants[[60]]$name #> [1] "W731L" #> #> $content$records[[8]]$variants[[60]]$id #> [1] 1571 #> #> $content$records[[8]]$variants[[60]]$evidence_items #> $content$records[[8]]$variants[[60]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[60]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[60]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[61]] #> $content$records[[8]]$variants[[61]]$name #> [1] "RARE EX 18-21 MUT" #> #> $content$records[[8]]$variants[[61]]$id #> [1] 1863 #> #> $content$records[[8]]$variants[[61]]$evidence_items #> $content$records[[8]]$variants[[61]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[61]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[61]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[62]] #> $content$records[[8]]$variants[[62]]$name #> [1] "R108K" #> #> $content$records[[8]]$variants[[62]]$id #> [1] 994 #> #> $content$records[[8]]$variants[[62]]$evidence_items #> $content$records[[8]]$variants[[62]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[62]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[62]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[63]] #> $content$records[[8]]$variants[[63]]$name #> [1] "V742A" #> #> $content$records[[8]]$variants[[63]]$id #> [1] 1001 #> #> $content$records[[8]]$variants[[63]]$evidence_items #> $content$records[[8]]$variants[[63]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[63]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[63]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[8]]$variants[[64]] #> $content$records[[8]]$variants[[64]]$name #> [1] "L861Q" #> #> $content$records[[8]]$variants[[64]]$id #> [1] 1020 #> #> $content$records[[8]]$variants[[64]]$evidence_items #> $content$records[[8]]$variants[[64]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[8]]$variants[[64]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[64]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[8]]$variants[[65]] #> $content$records[[8]]$variants[[65]]$name #> [1] "H773_V774insH" #> #> $content$records[[8]]$variants[[65]]$id #> [1] 1446 #> #> $content$records[[8]]$variants[[65]]$evidence_items #> $content$records[[8]]$variants[[65]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[65]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[65]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[66]] #> $content$records[[8]]$variants[[66]]$name #> [1] "D770_N771insGL" #> #> $content$records[[8]]$variants[[66]]$id #> [1] 1514 #> #> $content$records[[8]]$variants[[66]]$evidence_items #> $content$records[[8]]$variants[[66]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[66]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[66]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[67]] #> $content$records[[8]]$variants[[67]]$name #> [1] "AMPLIFICATION" #> #> $content$records[[8]]$variants[[67]]$id #> [1] 190 #> #> $content$records[[8]]$variants[[67]]$evidence_items #> $content$records[[8]]$variants[[67]]$evidence_items$accepted_count #> [1] 9 #> #> $content$records[[8]]$variants[[67]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[67]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[8]]$variants[[68]] #> $content$records[[8]]$variants[[68]]$name #> [1] "D770_N771insGY" #> #> $content$records[[8]]$variants[[68]]$id #> [1] 1666 #> #> $content$records[[8]]$variants[[68]]$evidence_items #> $content$records[[8]]$variants[[68]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[68]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[68]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[69]] #> $content$records[[8]]$variants[[69]]$name #> [1] "A864T" #> #> $content$records[[8]]$variants[[69]]$id #> [1] 1187 #> #> $content$records[[8]]$variants[[69]]$evidence_items #> $content$records[[8]]$variants[[69]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[69]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[69]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[70]] #> $content$records[[8]]$variants[[70]]$name #> [1] "P772_H773insYNP" #> #> $content$records[[8]]$variants[[70]]$id #> [1] 1667 #> #> $content$records[[8]]$variants[[70]]$evidence_items #> $content$records[[8]]$variants[[70]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[70]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[70]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[71]] #> $content$records[[8]]$variants[[71]]$name #> [1] "EXON 19 DELETION" #> #> $content$records[[8]]$variants[[71]]$id #> [1] 133 #> #> $content$records[[8]]$variants[[71]]$evidence_items #> $content$records[[8]]$variants[[71]]$evidence_items$accepted_count #> [1] 16 #> #> $content$records[[8]]$variants[[71]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[71]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[72]] #> $content$records[[8]]$variants[[72]]$name #> [1] "E734Q" #> #> $content$records[[8]]$variants[[72]]$id #> [1] 1572 #> #> $content$records[[8]]$variants[[72]]$evidence_items #> $content$records[[8]]$variants[[72]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[72]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[72]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[73]] #> $content$records[[8]]$variants[[73]]$name #> [1] "R451C" #> #> $content$records[[8]]$variants[[73]]$id #> [1] 454 #> #> $content$records[[8]]$variants[[73]]$evidence_items #> $content$records[[8]]$variants[[73]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[73]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[73]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[74]] #> $content$records[[8]]$variants[[74]]$name #> [1] "Gain-of-function" #> #> $content$records[[8]]$variants[[74]]$id #> [1] 1765 #> #> $content$records[[8]]$variants[[74]]$evidence_items #> $content$records[[8]]$variants[[74]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[74]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[74]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[75]] #> $content$records[[8]]$variants[[75]]$name #> [1] "P753S" #> #> $content$records[[8]]$variants[[75]]$id #> [1] 460 #> #> $content$records[[8]]$variants[[75]]$evidence_items #> $content$records[[8]]$variants[[75]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[75]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[75]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[76]] #> $content$records[[8]]$variants[[76]]$name #> [1] "C797Y" #> #> $content$records[[8]]$variants[[76]]$id #> [1] 1574 #> #> $content$records[[8]]$variants[[76]]$evidence_items #> $content$records[[8]]$variants[[76]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[76]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[76]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[8]]$variants[[77]] #> $content$records[[8]]$variants[[77]]$name #> [1] "M766_A767insAI" #> #> $content$records[[8]]$variants[[77]]$id #> [1] 1664 #> #> $content$records[[8]]$variants[[77]]$evidence_items #> $content$records[[8]]$variants[[77]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[8]]$variants[[77]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[8]]$variants[[77]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[8]]$aliases #> $content$records[[8]]$aliases[[1]] #> [1] "ERBB" #> #> $content$records[[8]]$aliases[[2]] #> [1] "EGFR" #> #> $content$records[[8]]$aliases[[3]] #> [1] "mENA" #> #> $content$records[[8]]$aliases[[4]] #> [1] "PIG61" #> #> $content$records[[8]]$aliases[[5]] #> [1] "NISBD2" #> #> $content$records[[8]]$aliases[[6]] #> [1] "HER1" #> #> $content$records[[8]]$aliases[[7]] #> [1] "ERBB1" #> #> #> $content$records[[8]]$type #> [1] "gene" #> #> #> $content$records[[9]] #> $content$records[[9]]$id #> [1] 20 #> #> $content$records[[9]]$name #> [1] "ERBB2" #> #> $content$records[[9]]$entrez_id #> [1] 2064 #> #> $content$records[[9]]$description #> [1] "ERBB2, commonly referred to as HER2, is amplified and/or overexpressed in 20-30% of invasive breast carcinomas. HER2-positive breast cancer is treated in a separate manner from other subtypes of breast cancer and commonly presents as more aggressive disease. Metastatic HER2-positive breast cancer is now commonly treated with HER2-targeted therapy. Apart from being amplified/overexpressed, ERBB2 activating mutations have been shown to have clinical importance in HER2-negative breast cancer. These mutations have shown sensitivity to the tyrosine kinase inhibitor neratinib, and highlight the importance of clinical sequencing efforts in treating breast cancer." #> #> $content$records[[9]]$variants #> $content$records[[9]]$variants[[1]] #> $content$records[[9]]$variants[[1]]$name #> [1] "L755S" #> #> $content$records[[9]]$variants[[1]]$id #> [1] 39 #> #> $content$records[[9]]$variants[[1]]$evidence_items #> $content$records[[9]]$variants[[1]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[9]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[1]]$evidence_items$submitted_count #> [1] 3 #> #> #> #> $content$records[[9]]$variants[[2]] #> $content$records[[9]]$variants[[2]]$name #> [1] "DEL 755-759" #> #> $content$records[[9]]$variants[[2]]$id #> [1] 37 #> #> $content$records[[9]]$variants[[2]]$evidence_items #> $content$records[[9]]$variants[[2]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[3]] #> $content$records[[9]]$variants[[3]]$name #> [1] "AMPLIFICATION" #> #> $content$records[[9]]$variants[[3]]$id #> [1] 306 #> #> $content$records[[9]]$variants[[3]]$evidence_items #> $content$records[[9]]$variants[[3]]$evidence_items$accepted_count #> [1] 58 #> #> $content$records[[9]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[3]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[9]]$variants[[4]] #> $content$records[[9]]$variants[[4]]$name #> [1] "KINASE DOMAIN MUTATION" #> #> $content$records[[9]]$variants[[4]]$id #> [1] 413 #> #> $content$records[[9]]$variants[[4]]$evidence_items #> $content$records[[9]]$variants[[4]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[9]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[4]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[5]] #> $content$records[[9]]$variants[[5]]$name #> [1] "G776L" #> #> $content$records[[9]]$variants[[5]]$id #> [1] 816 #> #> $content$records[[9]]$variants[[5]]$evidence_items #> $content$records[[9]]$variants[[5]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[5]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[6]] #> $content$records[[9]]$variants[[6]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[9]]$variants[[6]]$id #> [1] 875 #> #> $content$records[[9]]$variants[[6]]$evidence_items #> $content$records[[9]]$variants[[6]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[9]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[6]]$evidence_items$submitted_count #> [1] 7 #> #> #> #> $content$records[[9]]$variants[[7]] #> $content$records[[9]]$variants[[7]]$name #> [1] "L866M" #> #> $content$records[[9]]$variants[[7]]$id #> [1] 496 #> #> $content$records[[9]]$variants[[7]]$evidence_items #> $content$records[[9]]$variants[[7]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[7]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[9]]$variants[[8]] #> $content$records[[9]]$variants[[8]]$name #> [1] "SERUM LEVELS" #> #> $content$records[[9]]$variants[[8]]$id #> [1] 416 #> #> $content$records[[9]]$variants[[8]]$evidence_items #> $content$records[[9]]$variants[[8]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[9]]$variants[[8]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[8]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[9]] #> $content$records[[9]]$variants[[9]]$name #> [1] "V777L" #> #> $content$records[[9]]$variants[[9]]$id #> [1] 44 #> #> $content$records[[9]]$variants[[9]]$evidence_items #> $content$records[[9]]$variants[[9]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[9]]$variants[[9]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[9]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[9]]$variants[[10]] #> $content$records[[9]]$variants[[10]]$name #> [1] "Y772_A775DUP" #> #> $content$records[[9]]$variants[[10]]$id #> [1] 414 #> #> $content$records[[9]]$variants[[10]]$evidence_items #> $content$records[[9]]$variants[[10]]$evidence_items$accepted_count #> [1] 6 #> #> $content$records[[9]]$variants[[10]]$evidence_items$rejected_count #> [1] 2 #> #> $content$records[[9]]$variants[[10]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[9]]$variants[[11]] #> $content$records[[9]]$variants[[11]]$name #> [1] "G309A" #> #> $content$records[[9]]$variants[[11]]$id #> [1] 38 #> #> $content$records[[9]]$variants[[11]]$evidence_items #> $content$records[[9]]$variants[[11]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[11]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[11]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[12]] #> $content$records[[9]]$variants[[12]]$name #> [1] "L755W" #> #> $content$records[[9]]$variants[[12]]$id #> [1] 40 #> #> $content$records[[9]]$variants[[12]]$evidence_items #> $content$records[[9]]$variants[[12]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[12]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[12]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[13]] #> $content$records[[9]]$variants[[13]]$name #> [1] "T862A" #> #> $content$records[[9]]$variants[[13]]$id #> [1] 871 #> #> $content$records[[9]]$variants[[13]]$evidence_items #> $content$records[[9]]$variants[[13]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[13]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[13]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[14]] #> $content$records[[9]]$variants[[14]]$name #> [1] "M774DELINSWLV" #> #> $content$records[[9]]$variants[[14]]$id #> [1] 818 #> #> $content$records[[9]]$variants[[14]]$evidence_items #> $content$records[[9]]$variants[[14]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[14]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[14]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[15]] #> $content$records[[9]]$variants[[15]]$name #> [1] "S310F/Y" #> #> $content$records[[9]]$variants[[15]]$id #> [1] 497 #> #> $content$records[[9]]$variants[[15]]$evidence_items #> $content$records[[9]]$variants[[15]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[15]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[15]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[9]]$variants[[16]] #> $content$records[[9]]$variants[[16]]$name #> [1] "D769Y" #> #> $content$records[[9]]$variants[[16]]$id #> [1] 36 #> #> $content$records[[9]]$variants[[16]]$evidence_items #> $content$records[[9]]$variants[[16]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[16]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[16]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[17]] #> $content$records[[9]]$variants[[17]]$name #> [1] "R678Q" #> #> $content$records[[9]]$variants[[17]]$id #> [1] 42 #> #> $content$records[[9]]$variants[[17]]$evidence_items #> $content$records[[9]]$variants[[17]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[17]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[17]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[18]] #> $content$records[[9]]$variants[[18]]$name #> [1] "G778_P780DUP" #> #> $content$records[[9]]$variants[[18]]$id #> [1] 817 #> #> $content$records[[9]]$variants[[18]]$evidence_items #> $content$records[[9]]$variants[[18]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[9]]$variants[[18]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[18]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[19]] #> $content$records[[9]]$variants[[19]]$name #> [1] "R896C" #> #> $content$records[[9]]$variants[[19]]$id #> [1] 43 #> #> $content$records[[9]]$variants[[19]]$evidence_items #> $content$records[[9]]$variants[[19]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[19]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[19]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[20]] #> $content$records[[9]]$variants[[20]]$name #> [1] "MUTATION" #> #> $content$records[[9]]$variants[[20]]$id #> [1] 666 #> #> $content$records[[9]]$variants[[20]]$evidence_items #> $content$records[[9]]$variants[[20]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[9]]$variants[[20]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[20]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[21]] #> $content$records[[9]]$variants[[21]]$name #> [1] "V842I" #> #> $content$records[[9]]$variants[[21]]$id #> [1] 45 #> #> $content$records[[9]]$variants[[21]]$evidence_items #> $content$records[[9]]$variants[[21]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[9]]$variants[[21]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[21]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[9]]$variants[[22]] #> $content$records[[9]]$variants[[22]]$name #> [1] "N857S" #> #> $content$records[[9]]$variants[[22]]$id #> [1] 873 #> #> $content$records[[9]]$variants[[22]]$evidence_items #> $content$records[[9]]$variants[[22]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[22]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[22]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[23]] #> $content$records[[9]]$variants[[23]]$name #> [1] "H878Y" #> #> $content$records[[9]]$variants[[23]]$id #> [1] 874 #> #> $content$records[[9]]$variants[[23]]$evidence_items #> $content$records[[9]]$variants[[23]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[23]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[23]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[24]] #> $content$records[[9]]$variants[[24]]$name #> [1] "D769H" #> #> $content$records[[9]]$variants[[24]]$id #> [1] 35 #> #> $content$records[[9]]$variants[[24]]$evidence_items #> $content$records[[9]]$variants[[24]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[24]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[24]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[25]] #> $content$records[[9]]$variants[[25]]$name #> [1] "V773A" #> #> $content$records[[9]]$variants[[25]]$id #> [1] 872 #> #> $content$records[[9]]$variants[[25]]$evidence_items #> $content$records[[9]]$variants[[25]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[9]]$variants[[25]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[25]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[9]]$variants[[26]] #> $content$records[[9]]$variants[[26]]$name #> [1] "P780INS" #> #> $content$records[[9]]$variants[[26]]$id #> [1] 41 #> #> $content$records[[9]]$variants[[26]]$evidence_items #> $content$records[[9]]$variants[[26]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[9]]$variants[[26]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[9]]$variants[[26]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> #> $content$records[[9]]$aliases #> $content$records[[9]]$aliases[[1]] #> [1] "HER-2/neu" #> #> $content$records[[9]]$aliases[[2]] #> [1] "HER2" #> #> $content$records[[9]]$aliases[[3]] #> [1] "HER-2" #> #> $content$records[[9]]$aliases[[4]] #> [1] "CD340" #> #> $content$records[[9]]$aliases[[5]] #> [1] "MLN 19" #> #> $content$records[[9]]$aliases[[6]] #> [1] "NEU" #> #> $content$records[[9]]$aliases[[7]] #> [1] "NGL" #> #> $content$records[[9]]$aliases[[8]] #> [1] "TKR1" #> #> $content$records[[9]]$aliases[[9]] #> [1] "ERBB2" #> #> #> $content$records[[9]]$type #> [1] "gene" #> #> #> $content$records[[10]] #> $content$records[[10]]$id #> [1] 21 #> #> $content$records[[10]]$name #> [1] "ESR1" #> #> $content$records[[10]]$entrez_id #> [1] 2099 #> #> $content$records[[10]]$description #> [1] "ESR1 has been a focus in breast cancer for quite some time, but is also clinically relevant in endometrial, ovarian and other cancer types. The identification of ER-positive breast cancers that are resistant to hormone therapy have inspired clinical sequencing efforts to shed light on the mechanisms of this resistance. A number of mutations in the ligand binding domain of ESR1 have been implicated in hormone resistance and anti-estrogen therapies. These observations have spurred efforts to develop therapeutics that stimulate ESR1 protein degradation (e.g. Fulvestrant), rather than acting as a small molecule antagonist. These agents are currently in clinical trials and have seen some success." #> #> $content$records[[10]]$variants #> $content$records[[10]]$variants[[1]] #> $content$records[[10]]$variants[[1]]$name #> [1] "OVEREXPRESSION" #> #> $content$records[[10]]$variants[[1]]$id #> [1] 607 #> #> $content$records[[10]]$variants[[1]]$evidence_items #> $content$records[[10]]$variants[[1]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[10]]$variants[[1]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[1]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[10]]$variants[[2]] #> $content$records[[10]]$variants[[2]]$name #> [1] "L536Q" #> #> $content$records[[10]]$variants[[2]]$id #> [1] 46 #> #> $content$records[[10]]$variants[[2]]$evidence_items #> $content$records[[10]]$variants[[2]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[10]]$variants[[2]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[2]]$evidence_items$submitted_count #> [1] 0 #> #> #> #> $content$records[[10]]$variants[[3]] #> $content$records[[10]]$variants[[3]]$name #> [1] "S463P" #> #> $content$records[[10]]$variants[[3]]$id #> [1] 692 #> #> $content$records[[10]]$variants[[3]]$evidence_items #> $content$records[[10]]$variants[[3]]$evidence_items$accepted_count #> [1] 1 #> #> $content$records[[10]]$variants[[3]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[3]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[10]]$variants[[4]] #> $content$records[[10]]$variants[[4]]$name #> [1] "D538G" #> #> $content$records[[10]]$variants[[4]]$id #> [1] 47 #> #> $content$records[[10]]$variants[[4]]$evidence_items #> $content$records[[10]]$variants[[4]]$evidence_items$accepted_count #> [1] 3 #> #> $content$records[[10]]$variants[[4]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[4]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[10]]$variants[[5]] #> $content$records[[10]]$variants[[5]]$name #> [1] "Y537S" #> #> $content$records[[10]]$variants[[5]]$id #> [1] 50 #> #> $content$records[[10]]$variants[[5]]$evidence_items #> $content$records[[10]]$variants[[5]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[10]]$variants[[5]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[5]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> $content$records[[10]]$variants[[6]] #> $content$records[[10]]$variants[[6]]$name #> [1] "Y537C" #> #> $content$records[[10]]$variants[[6]]$id #> [1] 48 #> #> $content$records[[10]]$variants[[6]]$evidence_items #> $content$records[[10]]$variants[[6]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[10]]$variants[[6]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[6]]$evidence_items$submitted_count #> [1] 1 #> #> #> #> $content$records[[10]]$variants[[7]] #> $content$records[[10]]$variants[[7]]$name #> [1] "Y537N" #> #> $content$records[[10]]$variants[[7]]$id #> [1] 49 #> #> $content$records[[10]]$variants[[7]]$evidence_items #> $content$records[[10]]$variants[[7]]$evidence_items$accepted_count #> [1] 2 #> #> $content$records[[10]]$variants[[7]]$evidence_items$rejected_count #> [1] 0 #> #> $content$records[[10]]$variants[[7]]$evidence_items$submitted_count #> [1] 2 #> #> #> #> #> $content$records[[10]]$aliases #> $content$records[[10]]$aliases[[1]] #> [1] "NR3A1" #> #> $content$records[[10]]$aliases[[2]] #> [1] "Era" #> #> $content$records[[10]]$aliases[[3]] #> [1] "ESTRR" #> #> $content$records[[10]]$aliases[[4]] #> [1] "ESRA" #> #> $content$records[[10]]$aliases[[5]] #> [1] "ESR" #> #> $content$records[[10]]$aliases[[6]] #> [1] "ER" #> #> $content$records[[10]]$aliases[[7]] #> [1] "ESR1" #> #> #> $content$records[[10]]$type #> [1] "gene" #> #> #> #> #> $url #> [1] "https://civicdb.org/api/genes" #> #> $response #> Response [https://civicdb.org/api/genes?page=2&count=10] #> Date: 2019-09-03 16:44 #> Status: 200 #> Content-Type: application/json; charset=utf-8 #> Size: 22.1 kB #> #> #> attr(,"class") #> [1] "civic_api"